ID A0A2K6ERX9_PROCO Unreviewed; 1069 AA.
AC A0A2K6ERX9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G5 {ECO:0000313|Ensembl:ENSPCOP00000004487.1};
GN Name=PLEKHG5 {ECO:0000313|Ensembl:ENSPCOP00000004487.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000004487.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000004487.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6ERX9; -.
DR Ensembl; ENSPCOT00000014649.1; ENSPCOP00000004487.1; ENSPCOG00000012736.1.
DR GeneTree; ENSGT00510000046843; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd17068; RBD_PLEKHG5; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13217:SF11; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5; 1.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT DOMAIN 402..594
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 650..750
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..791
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..923
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 117878 MW; C9449E1FEAD5FA5D CRC64;
MGTGPGVSGR RAASRPGLGL PSRAPEPSWA GGRARDGEGQ VCHHADCQQL HRRGPLNLCE
ACDSKFHSTM HYDGHVRFDL PPQGSVLARN VSTRSCPPRT SPAVDLEEEE ESSVDSKGGP
KAESQTGDSE TRCFGDPSKE CFTLKFDLNV DIETEIVPAM KKKSLGEVLL PVFERKGIAL
GKVDIYLDQS NTPLSLTFEA YRFGGHYLRV KAKPGDEGKV EQGVKDSKSL SLPILRPAGP
GPPMLERVDP QSRWENLDIL APGRRRKNMS EFLGEASIPG QEPLTPSSCS LPSSSSGGAS
SGGGDSWKNR AASRFSGFFS SGPSTSTFSR EVDKMEQLES KLHTYGLFGL PRLPRRLRFD
HDSWEEEEDE EDEDEDSACL RLEDSWRELI NGHEKLTRRQ CHQQEAVWEL LHTEASYIRK
LRVITNLFLC CLLNLQESGL LCEVEAERLF SNIPEIARLH RGLWGSVMAP VLEKARRTRA
LLQPGDFLKG FKMFGSLFKP YVRYCMEEEG CMEYMRGLLR DNDLFRAYVT WAEKQPQCQR
LKLSDMLAKP HQRLTKYPLL LKSVLRKTDE PRAKEAVVTM IGSVERFIHH VNTCMRQRQE
RQRLAAVASR IDAYEVVEGS NDEVDKLLKE FLHLDLTVPI SGAPLEETRQ LLLEGSLRMK
EGKDSKMDVY CFLFTDLLLV TKAVKKAERT KVIRPPLLVD KIVCRELRDP GSFLLIYLNE
FHSAVGAYTF QASGQALCRG WVDAIYNAQN QLQQLRAQEH PSSQQHLQSL VEEEDEQEEE
EEEEEEEGEE SSTSAASSPT ILRRSSNSPD SQHCASDGST ETLAMVVVEP EEVLSSPEFD
GGPFSSQSDE TSLSTTASSV TPTSELLPLG LVDGCSCSMD SAYGTLSPTS LQDFAAPAPV
AEPVPQLPEL PRAPSPPPSP RLRRRTPVQL LPCLPHLLKS KSEASLLQLL PGAGTHAPSP
APSRSLSELC LAAIAPGART QGCSLEAGPS WDYTGASSPG SSSKPLDCLA EEPAGPSRRC
RELPLGSSPR IQPDAPTGAS AQHRKLTLAQ LYRIRTTLLL NSTLTASEG
//
