ID A0A2K6EUM0_PROCO Unreviewed; 317 AA.
AC A0A2K6EUM0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Glyoxylate and hydroxypyruvate reductase {ECO:0000313|Ensembl:ENSPCOP00000005430.1};
GN Name=GRHPR {ECO:0000313|Ensembl:ENSPCOP00000005430.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000005430.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000005430.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR AlphaFoldDB; A0A2K6EUM0; -.
DR Ensembl; ENSPCOT00000015811.1; ENSPCOP00000005430.1; ENSPCOG00000013619.1.
DR GeneTree; ENSGT00940000158578; -.
DR OMA; IAWAYSD; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF137; GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT DOMAIN 9..315
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 125..284
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 317 AA; 34562 MW; 04FE53EA2034B368 CRC64;
MRPVRLMKVF ITRRIPPEGI AALTRAADCE VEQWDSDEPI PDKELERGLA GAHGLLCLLS
DRVDKRLLDA AGANLKVIST LSVGVDHLAL DEIKKRGIRV GYTPDVLTDT TAELAMSLLL
TTCRGGWTTW KPLWMCGYGL TQSTVGIIGL GRIGQAIARR LKPFGVQRYL YTGRQPRPEE
AAEFQAEFVS VPQLAAQSDF IVVACSLTPA TRGLCNKDFF QKMKKTAVFV NISRGDVVNQ
DDLYQALASG QIAAAGLDVT TPEPLPTNHP LLTLKNCVIL PHIGSATYRT RNTMSLLAAN
NLLAGLRGEP MPSELKL
//
