ID   A0A2K6EV19_PROCO        Unreviewed;      1165 AA.
AC   A0A2K6EV19;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 5 {ECO:0000313|Ensembl:ENSPCOP00000005563.1};
GN   Name=TRPM5 {ECO:0000313|Ensembl:ENSPCOP00000005563.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000005563.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000005563.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_012507488.1; XM_012652034.1.
DR   AlphaFoldDB; A0A2K6EV19; -.
DR   STRING; 379532.ENSPCOP00000005563; -.
DR   Ensembl; ENSPCOT00000015958.1; ENSPCOP00000005563.1; ENSPCOG00000013713.1.
DR   GeneID; 105816564; -.
DR   CTD; 29850; -.
DR   GeneTree; ENSGT00940000160588; -.
DR   OMA; CYCTAVI; -.
DR   OrthoDB; 201873at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005267; F:potassium channel activity; IEA:Ensembl.
DR   GO; GO:0005272; F:sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        729..755
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        813..832
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        875..896
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        951..971
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..268
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          743..987
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1131..1165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1165 AA;  130869 MW;  3D07153FA37D76DB CRC64;
     MQDARGSCPG SPRDAADGQG PGLCRGEINF GGSGKKRGKF VKVPSSVAPS VLFDLLLTKW
     HLPAPNLVVS LVGEERPFAM KSWLRDVLRK ALVKAAQTTG AWILTSALRV GSAWHIGQAV
     RDHSLASTST KVRVVAIGIA SLGRVLHRRL LEDAQEDIPA HYPAEDGGSS QGPLCPLDSN
     LSHFILVEPG PPGKEDGLTG LRLRLEKHIS EQRTGYGGTG SIEIPVLCLL VNGDPGALER
     VSRAVEQAAP WLILAGSGGV ADVLAALVSQ PHPLVPQVVE KQFKEKFPSE RFSWEDIVHW
     TKLLQNITAH PHLLTVHDFE QEGSEELDTV ILKALVKACK SHSQEAQDYL DELKLAVAWD
     RVDIAKSEIF NGDVEWKSRD LEEVMMDALV SNKPEFVRLF VDNGADVADF LTYGRLQQLY
     RSVAPKSLLF DLLQRKHEEA RRTLAGLGTQ PPREPPAGPP AFSLHEVSRV LKDFLRDACR
     GLYQDGGPGS RRKVERGPAK RPTGQKWLPD LGQRSEQPWR DLFLWAVLQN RHEMATYFWA
     MGQEGVAAAL AACKILKEMS HLEPEAEVAR AMREAKYEQL ALDLFSECYS NSEDRAFALL
     VRRNRCWSRT TCLHLATEAD TKAFFAHDGV QAFLTKIWWG DMATGTPILR LLGAFFCPPL
     VYTSLITFRE EAPLRTGPED LQELDGLGAE NSPLCGPGSL VEELAEAPRA QGDRGPHVAF
     LLTRWRKFWG APVTVFLGNV VMYFAFLFLF TYVLLVDFRP PSQGPSVAEV TLYFWVFTLV
     LEEIRQGFFT DEDTHLLKKF TLYVEDNWNK CDMVAIFLFI IGVTCRMLPS VFEAGRSVLA
     MDFMVFTLRL IHIFAIHKQL GPKIIIVERM MKDVFFFLFF LSVWLVAYGV TTQALLHPHD
     SRLEWIFRRV LYRPYLQIFG QIPLDEIDEA RVNCSAHPLL LQSSPSCPNL YANWLVILLL
     VTFLLVTNVL LMNLLIAMFS YTFQVVQGNA DMFWKFQRYH LIVEYHERPA LAPPFILLSH
     LSLALSRAIR KTEHKREHLE RDLPDPLDQQ VVTWETVQKE NFLSRVEKRR RDSEGEVLRK
     TAHRVDVVAK YLGGLREQDK RIKSLESQVN YCTMLLSSVA DTLAQGSVPW SSRNCGNGSR
     QAAADHRGDP GGREHPQPGQ PPSDT
//