ID A0A2K6EZQ5_PROCO Unreviewed; 227 AA.
AC A0A2K6EZQ5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
GN Name=TRH {ECO:0000313|Ensembl:ENSPCOP00000007197.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000007197.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000007197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC {ECO:0000256|PIRNR:PIRNR001795}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437,
CC ECO:0000256|PIRNR:PIRNR001795}.
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DR RefSeq; XP_012512349.1; XM_012656895.1.
DR AlphaFoldDB; A0A2K6EZQ5; -.
DR STRING; 379532.ENSPCOP00000007197; -.
DR Ensembl; ENSPCOT00000017739.1; ENSPCOP00000007197.1; ENSPCOG00000014823.1.
DR GeneID; 105820420; -.
DR KEGG; pcoq:105820420; -.
DR CTD; 7200; -.
DR GeneTree; ENSGT00390000016951; -.
DR OMA; QESFTCN; -.
DR OrthoDB; 5356148at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001795};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR001795}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT CHAIN 22..227
FT /note="Pro-thyrotropin-releasing hormone"
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT /id="PRO_5014212712"
FT REGION 40..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 25220 MW; 62C45E00B6C0619B CRC64;
MPGPWLLLAL AVTLAPAGTD GAQREAAPLR RAGPLLFLRE GLRAPQGDRS ARSESQILPP
NWLSKRQHPG KREEEAEEGL EEEEEEEWGA GGPHKRQHPG RREDDAWWAA DGTQHKRQHP
GRRAPWPGYA VTKRQHPGRR LVEPQAQRNW DEEEEEGEGE GEEDLTAEKR QHPGRRSPGG
PCGPQGACGR ASVLRGLLGD PSRGQGAEEQ RQHPGRRAAW VREPLQA
//
