UniProt: A0A2K6F0K6

Database: UniProt
Entry: A0A2K6F0K6_PROCO

LinkDB:  A0A2K6F0K6_PROCO 
Original site:  A0A2K6F0K6_PROCO

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Ontology (25)   
   GO (25)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (19)   
   InterPro (11)   
   Pfam (5)   
   PROSITE (1)   
   SMART (2)   
All databases (47)   

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ID   A0A2K6F0K6_PROCO        Unreviewed;      1229 AA.
AC   A0A2K6F0K6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN   Name=MSH6 {ECO:0000313|Ensembl:ENSPCOP00000007510.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000007510.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000007510.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC       (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR   AlphaFoldDB; A0A2K6F0K6; -.
DR   STRING; 379532.ENSPCOP00000007510; -.
DR   Ensembl; ENSPCOT00000018053.1; ENSPCOP00000007510.1; ENSPCOG00000014994.1.
DR   GeneTree; ENSGT00550000075024; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0032301; C:MutSalpha complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043531; F:ADP binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0000400; F:four-way junction DNA binding; IEA:Ensembl.
DR   GO; GO:0032137; F:guanine/thymine mispair binding; IEA:Ensembl.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR   GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR   GO; GO:0032405; F:MutLalpha complex binding; IEA:Ensembl.
DR   GO; GO:0032357; F:oxidized purine DNA binding; IEA:Ensembl.
DR   GO; GO:0032142; F:single guanine insertion binding; IEA:Ensembl.
DR   GO; GO:0032143; F:single thymine insertion binding; IEA:Ensembl.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR   GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR   GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:Ensembl.
DR   GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR   GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW   DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR037677};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          1077..1093
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          1..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1229 AA;  137699 MW;  737E4B4203CD2E3F CRC64;
     MSRQSTLYNF FPKSPALNNS NKALTRASRE GGGAAAATRA SPSPGGDAAW SEAGPGPRPL
     AGSASPPEAK KLNGGLQRSV GTTYVSDKSE EDNEIESDEE VQPKMQGSRR SSRQIKKRRV
     ISDSESDIGG SDVEFKPDTK EEGSSDEISS GMGDSESEGF DSPVKVARKR KKMAGNGSLK
     RKSSRKEMPS ATKRATGISS ETKSTLNAFS ASQNSESQAH ISGGGDDSGR PTIWYHETLE
     WLKKEKRRDE HRRRPDHPDF DASTLYVPED FLNSCTPGMR KWWQIKSQNF DLVIFYKVGK
     FYELYHMDAL IGVNELGLVF MKGNWAHSGF PEIAFGRYSD SLVQKGYKVA RVEQTETPEM
     MEARCRKMAH ISKHDRVVRR EICRVITKGT QTYSVLEGDP SENYSKYLLS LKEKEDSSGH
     TRVYGVCFVD TSLGKFFIGQ FSDDRHCSRF RTLVAHYPPV QVLFEKGNLS VETKTVLKGS
     LSSCLQEGLI PGSQFWDASK TLRTLLEEGY FREKLNEDSG VMLPQVLKDM TSESDSIGLT
     PGEKSELALS ALGGCVFYLK KCLIDQELLS MANFEEYIPL DSDIVSTTSP GAIFTKTNQR
     MVLDAVTLSN LEIFQNGTNG STEGTLLERV DTCHTPFGKR LLKQWLSAPL CSPYAISDRL
     DAIEDLMVVP DKISEVVDLL KKLPDLERLL SKIHNVGSPM KSQNHPDSRA IMYEETTYSK
     KKIIDFLSAL EGFKVICKII GIMEEVVDNF KSKILKQVIT LQTKNSEGRF PDLTIELNRW
     DTAFDHEKAR KTGLITPKAG FDSDYDQALA DIRENEQSLL EYLEKQRSRI GCRTIVYWGI
     GRNRYQLEIP ENFTTRNLPE EYELKSTKKG CKRYWTKTIE KKLANLINAE ERRDVSLKDC
     MRRLFYNFDK NYKDWQTAVE CMAVLDVLLC LANYSRGGDG PMCRPVILLP GEDTAPFLKL
     KGSRHPCITK TFFGDDFIPN DILIGCEEEE EENGKAYCVL VTGPNMGGKS TLMRQAGLLA
     VMAQMGCYVP AEVCRLTPID RVFTRLGASD RIMSGESTFF VELSETASIL MHATAHSLVL
     VDELGRGTAT FDGTAIANAV VKELAETIKC RTLFSTHYHS LVEDYSQNVA VRLGHMACMV
     ENECEDPSQE TITFLYKFIK GACPKSYGFN AARLANLPEE VIQKGHRKAR EFEKMNQSLR
     LFREVCLASE RSTIDAEAVH KLLTLIKEL
//

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