ID   A0A2K6F174_PROCO        Unreviewed;       686 AA.
AC   A0A2K6F174;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Axin 2 {ECO:0000313|Ensembl:ENSPCOP00000007738.1};
GN   Name=AXIN2 {ECO:0000313|Ensembl:ENSPCOP00000007738.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000007738.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000007738.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6F174; -.
DR   Ensembl; ENSPCOT00000018285.1; ENSPCOP00000007738.1; ENSPCOG00000015119.1.
DR   GeneTree; ENSGT00940000157338; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd11582; Axin_TNKS_binding; 1.
DR   CDD; cd08707; RGS_Axin; 1.
DR   Gene3D; 1.10.196.10; -; 1.
DR   Gene3D; 2.40.240.130; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR043581; Axin-like.
DR   InterPro; IPR014936; Axin_b-cat-bd.
DR   InterPro; IPR032101; Axin_TNKS-bd.
DR   InterPro; IPR001158; DIX.
DR   InterPro; IPR038207; DIX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46102; AXIN; 1.
DR   PANTHER; PTHR46102:SF1; AXIN-2; 1.
DR   Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR   Pfam; PF08833; Axin_b-cat_bind; 1.
DR   Pfam; PF00778; DIX; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00021; DAX; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50841; DIX; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW   ProRule:PRU00069}.
FT   DOMAIN          81..200
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          604..686
FT                   /note="DIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50841"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          447..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  76745 MW;  4FEC3951CBCBBE5F CRC64;
     MSSAVLVTRL PDPSSSFRED APRPPVPGEE GETPPCQLGV GKGQVTKPMP VSSNTRRNED
     GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM
     NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK PATKTYIRDG IKKQQIDSIM FDQAQTEIQS
     VMEENAYQMF LTSDIYLEYV RSGGENTAYM SNGALGSLKV VCGYLPTLNE EEEWTCADFK
     CKLSPTVVGL SSKTLRATAS VRSTETVESG YRSFKRSDPV NPYHVGAGYV FAPATSANDS
     EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK
     EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEGPELA VSSRDGAPTQ
     HPLSLLPSGS YEEDPQTILD DHLSRVLKTP GCHPRSRSPD HHHHHQQYHS LPPPGGKLPP
     TSASPGACPL FGGKGFVTKQ TTKHVHHHYI HHHAVPKTKE EIEAEATQRV RCFCPGGAEF
     YCYSKCKSHP KALEPMPGEQ FGQQRDRNHS GTVQAGAMPF SNPCLAPEDH KEPKKLAGVH
     TLQANELVVT YFFCGEEIPY RRMLKAQSLT LGHFKEQLSK KGNYRYYFKK ASDEFACGAV
     FEEVWDDETV LPMYEGRILG KVERID
//