ID   A0A2K6F5S6_PROCO        Unreviewed;      1080 AA.
AC   A0A2K6F5S6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000009345.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000009345.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Potential calcium-dependent cell-adhesion protein.
CC       {ECO:0000256|ARBA:ARBA00037723}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6F5S6; -.
DR   Ensembl; ENSPCOT00000019912.1; ENSPCOP00000009345.1; ENSPCOG00000016036.1.
DR   GeneTree; ENSGT00940000158335; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 7.
DR   Gene3D; 2.60.40.60; Cadherins; 7.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   InterPro; IPR013585; Protocadherin.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF254; PROTOCADHERIN-11 X-LINKED-RELATED; 1.
DR   Pfam; PF00028; Cadherin; 6.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF08374; Protocadherin; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 4.
DR   PROSITE; PS50268; CADHERIN_2; 7.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        867..888
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          107..193
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          194..303
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          304..409
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          416..520
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          521..624
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          625..727
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          739..849
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   1080 AA;  119553 MW;  FCFBB9E2A3866A2C CRC64;
     MFTVGFLIIS SSSSLLSLSL SLSSFLLLFL FFFLIFSLTA FCGETQRTFV IIIGMDLLSG
     TYIFAVLLAC VVFQSGAQEK NYTIREEMPE NVLIGDLWKD LNLSLIPDKS LTSPMKFKLV
     YKTGEVPLIR IEEDTGEIFT TGARIDREKL CSGILMDGQC FYEVEVAILP DEIFRLIKIR
     FLIEDINDNA PLFPTTVINI SIPENSAINS RFALPAAVDP DIGINGVQNY HLIKGQNIFG
     LDVIETPEGD KMPQLIVQKE LDREEKDTYV MKVKVEDGGF PQRSSTAILQ VSVADTNDNH
     PVFKEEEIEV SIPENAPIGT SVTQLHATDA DIGENARIHF YFSNLVSNVA KRLFHLNTTT
     GLITIKEPLD REESPNHKLL VLASDGGSMP ARAMVLVNVT DVNDNVPSID IRHIINPING
     TIVLSENAPL NTKVALITVT DKDADHNGRV TCFTDHEVPF RLRPVFSNQF LLETAAYLDY
     ESTKEYAIKL LAADAGTPPL NQSSMLLIKV KDENDNAPVF TQPFISLSVP ENNFPGSQLT
     KISATDADSG RNAEINYLLD TDAPPEFSVD RRTGILTALK KLDRENQEKY FFTALAKDNG
     VPPLISNVTV FVTVLDQNDN SPLFTHNEYN FYVPENLPRH GTVGLITVTD PDYGENSAVT
     LSILDVNDDF TIDPQTGVIR PNISFDREKQ ESYTFYVKAE DGGRVSRSTT AKVTINVVDV
     NDNKPVFVVP PSNYSYELVL PSTNPGTVIF KVVAIDNDTG MNAELRYSIV GGNTKDLFTI
     DETTGNITLQ EKCVATDLGL HKLIVKAEDL GQPDSLFNVV TVNLFVNESV TNATLIHELV
     RKSIETPVTQ NIETADTSSP TSDYVKIVVA IVAGTITVVL VIFIAAVVRC RHSPHLKAAQ
     KNKQNSEWAT PNPENRQMIM MKKKKKKKKK HAPKNLLLNF VTIEETKADD ADNDGNSVTL
     DLPIELEEQT MGRYNWGTTP TTFKPDSPDL ARHYKSASPQ PAFQIQPETP LNSKHHIIQE
     LPLDNTFVAC DSISKCSSSS SDPYSVSECS YPVTTFKTPV SVHTRPTDSR TSTIEICSEI
//