ID   A0A2K6F7M7_PROCO        Unreviewed;       512 AA.
AC   A0A2K6F7M7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=ETS variant transcription factor 3 {ECO:0000313|Ensembl:ENSPCOP00000009978.1};
GN   Name=ETV3 {ECO:0000313|Ensembl:ENSPCOP00000009978.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000009978.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000009978.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC       ECO:0000256|RuleBase:RU004019}.
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DR   RefSeq; XP_012514387.1; XM_012658933.1.
DR   RefSeq; XP_012514389.1; XM_012658935.1.
DR   AlphaFoldDB; A0A2K6F7M7; -.
DR   STRING; 379532.ENSPCOP00000009978; -.
DR   Ensembl; ENSPCOT00000020552.1; ENSPCOP00000009978.1; ENSPCOG00000016398.1.
DR   GeneID; 105822009; -.
DR   KEGG; pcoq:105822009; -.
DR   CTD; 2117; -.
DR   GeneTree; ENSGT00940000160963; -.
DR   OMA; DTHSPTN; -.
DR   OrthoDB; 4182934at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0090571; C:RNA polymerase II transcription repressor complex; IEA:Ensembl.
DR   GO; GO:0017151; F:DEAD/H-box RNA helicase binding; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF306; ETS TRANSLOCATION VARIANT 3; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW   Nucleus {ECO:0000256|RuleBase:RU004019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          35..116
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          136..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..407
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..490
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  57123 MW;  D08BAC5AC9F7FBCE CRC64;
     MKAGCSIVEK PEGGGGYQFP DWAYKTESSP GSRQIQLWHF ILELLQKEEF RHVIAWQQGE
     YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK RILHKTKGKR FTYKFNFNKL
     VMPNYPFINI RSSGVVPQSA PPVPTASSRF HFPPLDTHSP TSDMQPGRFS ASSLTTSQES
     SNGTDRKAEL SELEDGSATD WHRGMDHISS RNAVSGGGIG HQKRKPDIML PLFTRPGMYP
     DPHSPFAVSP IPGRGGVLNV PISPALSLTP TIFSYSPSPG LSPFTSSSCF SFNPEEMKHY
     LHSQACSVFN YHLSPRTFPR YPGLMVPPLQ CQMHPEESAQ FSIKLQPPPV GRKNRERVES
     NEESAPVAAP TMAPVPPRIK VEPASEKDPE SLRQSAREKE EHAQEEGGTV PSRTIEEGKG
     TIFARPTAPP IWPPVPISSP SEEPLEVTED SEDRSGKEPS APEKKEDALM PPKLRLKRRW
     NDDPEARELS KNGKFLWNGS GPRGLATAAA DA
//