ID A0A2K6F7U4_PROCO Unreviewed; 1162 AA.
AC A0A2K6F7U4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Cartilage intermediate layer protein 2 {ECO:0000313|Ensembl:ENSPCOP00000010043.1};
GN Name=CILP2 {ECO:0000313|Ensembl:ENSPCOP00000010043.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000010043.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000010043.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_012509545.1; XM_012654091.1.
DR AlphaFoldDB; A0A2K6F7U4; -.
DR STRING; 379532.ENSPCOP00000010043; -.
DR Ensembl; ENSPCOT00000020618.1; ENSPCOP00000010043.1; ENSPCOG00000016451.1.
DR GeneID; 105818167; -.
DR KEGG; pcoq:105818167; -.
DR CTD; 148113; -.
DR GeneTree; ENSGT00390000008152; -.
DR OMA; CGVRRME; -.
DR OrthoDB; 5383253at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR039675; CILP1/CILP2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR15031:SF0; CARTILAGE INTERMEDIATE LAYER PROTEIN 2; 1.
DR PANTHER; PTHR15031; CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13330; Mucin2_WxxW; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1162
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014364092"
FT DOMAIN 298..382
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1142..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 126895 MW; 57FF2B67DD1795BD CRC64;
MASLPRLLCL CVAAAHLAGA RDTTSTEEPT ATAWGLEGRS VHPDQPSPAL EDWEARAVPA
EASEWTSWFN VDHPGGDGDF ESLAAIRFYY GPARVCPRPL ALEARTTDWA LPSAVGERVH
VNPTRGFWCL NREQPRGRRC SNYHVRFRCP LETAWGAWGP WGPCSGSCGP GRRLRRRRCP
SPSGDACPGR TLEAQKCVRP RCPECSPDTC ECPNHILLGS VVTRSGQPLP GARVSLRDRP
GTIATSDAHG TFRVPGVCAD SQASVRAHMD GFSAGMAQAQ ANGSVSTVTI VLDKLQKPYL
VKHPKSRVRE AGQNVTFCCK ASGTPMPKKY SWFHNGTLLD RRAHRYGAHL ELWGLRPDQA
GIYHCKAWNE AGAVRSSTAR LTVLAPGQPA CDPQPREYLV KLPDDCGQPG SGPTYLDVGL
CPDTRCPSPA GWGPRCGDDG SRCCSVRRLQ SREIHCSGYV LPVKVVAECG CQKCLPPRGL
VRGRVVAADS GEPLRFARIL LGREPIGFTS YQGDFTIEVP PSTERLVVTF LDPSGEFMDA
VRVLPFDPRG AGVYHEVKAM RKKAPIVLDA SQSNTIPLGE LEDEAPLGEL VLPPGAFRSA
DGKRYSGPVE ARVTFVDPRD LTSATAAPSD LRFVDSDGEL APLRTYGMFS VDLRAPGSVE
QLQAGPVAVR VASDQIRMAG HAEALKLWSL NPETGLWEEE SGFRQEGSSG SRVRREERVF
LAGNVEIRER RLFNLDVPER RRCFVKVRAY ANDKFSPGEQ VEGVVVTLVN LEPAPGFSAN
PRAWGRFDSA VTGPNGACLP AFCDADRPDA YTALVTATLG GEELEPAPSL PRPLAATVGV
AQPYLDRLGY RRTDHDDPAF KRNGFRINLA KPRPGDPAEA NGPVYPWRSL RECQEAPVTA
SHFRFSRVEA DKYEYNVVPF REGAPASWTG DLLAWWPNPQ EFRACFLKVK IQGPQEYMVR
AHNAGGSHPR TQGQLYGLRD ARSVRDPQRQ GTSAACVEFK CSGMLFDQRQ VDRTLVTIVP
QGSCRRVAVN GLLRDYLARH PPPVPADDPA AFAMLAPLDP LGHNYGVYTV TDQSPRLAKE
IAIGRCFDGS SDGFSREMKA DAGTAVTFQC REPVAGRPSL FQRLLESPAT ALGDIRREMG
EVSRAQARAS GPLRTRRGRG RQ
//
