ID A0A2K6F819_PROCO Unreviewed; 1084 AA.
AC A0A2K6F819;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Importin 5 {ECO:0000313|Ensembl:ENSPCOP00000010118.1};
GN Name=IPO5 {ECO:0000313|Ensembl:ENSPCOP00000010118.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000010118.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000010118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K6F819; -.
DR Ensembl; ENSPCOT00000020693.1; ENSPCOP00000010118.1; ENSPCOG00000016473.1.
DR GeneTree; ENSGT00940000155502; -.
DR OMA; PKRFVQE; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR040928; Importin_rep_5.
DR InterPro; IPR041389; Importin_rep_6.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF22; IMPORTIN-5; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18816; Importin_rep_5; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 57..111
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1084 AA; 122086 MW; 3368E871F06B785D CRC64;
NLAAENTVPT YAMAATAAEQ QQFYLLLGNL LSPDNVVRKQ AEETYENIPG QSKITFLLQA
IRNTTAAEEA RQMAAVLLRR LLSSAFDEVY PTLPSDVQTA IKSELLMIIQ METQSSMRKK
ICDIAAELAR NLIDEDGNNQ WPEGLKFLFD SVSSQNVGLR EAALHIFWNF PGIFGNQQQH
YLDVIKRMLV QCMQDQEHPP IRTLSARATA AFILANEHNV ALFKHFSDLL PGFLQAVNDS
CYQNDDSVLK SLVEIADTVP KYLRPHLEAT LQLSLKLCGD TSLNNMQRQL ALEVIVTLSE
TAAAMLRKHT NIVAQTIPQM LAMMVDLEED EDWANADELE DDDFDSNAVA GESALDRMAC
GLGGKLVLPM IKEHIMQMLQ NPDWKYRHAG LMALSAIGEG CHQQMEGILN EIVNFVLLFL
QDPHPRVRYA ACNAVGQMAT DFAPGFQKKF HEKVIAALLQ TMEDQGNQRV QAHAAAALIN
FTEDCTKLVL EQVVTSIASV ADTAEEKFVP YYDLFMPSLK HIVENAVQKE LRLLRGKTIE
CISLIGLAVG KEKFMQDASD VMQLLLKTQT DFNDMEDDDP QISYMISAWA RMCKILGKEF
QQYLPVVMGP LMKTASIKPE VALLDTQDME NMSDDDGWEF VNLGDQQSFG IKTAGLEEKS
TACQMLVCYA KELKEGFVEY TEQVVKLMSN LLKFISDCIS LMIKRVRVAA AESMPLLLEC
ARVRGPEYLT QMWHFMCDAL IKAIGTEPDS DVLSEIMHSF AKCIEVMGDG CLNNEHFEEL
GGILKAKLEE HFKNQELRQV KRQDEDYDEQ VEESLQDEDD NDVYILTKVS DILHSIFSSY
KEKVLPWFEQ LLPLIVNLIC PHRPWPDRQW GLCIFDDIIE HCSPSSFKYA EYFLRPMLQY
VCDNIPEVRQ AAAYGLGVMA QYGGDNYRPF CTEALPLLVR VIQSADSKTK ENVNATENCI
SAVGKIMKFK PDCVNVEEVL PHWLSWLPLH EDKEEAVQTF SYLCDLIESN HPIVLGPNNT
NLPKIFSIIA EGEMHEAIKH EDPCAKRLAN VVRQVQTSGG LWTECIAQLS PEQQAAIQEL
LNSA
//
