ID   A0A2K6F9W3_PROCO        Unreviewed;       694 AA.
AC   A0A2K6F9W3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Interleukin 12 receptor subunit beta 2 {ECO:0000313|Ensembl:ENSPCOP00000010775.1};
GN   Name=IL12RB2 {ECO:0000313|Ensembl:ENSPCOP00000010775.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000010775.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000010775.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC       subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR   AlphaFoldDB; A0A2K6F9W3; -.
DR   Ensembl; ENSPCOT00000021356.1; ENSPCOP00000010775.1; ENSPCOG00000016862.1.
DR   GeneTree; ENSGT00940000159829; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR010457; IgC2-like_lig-bd.
DR   PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23036:SF79; INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF06328; Lep_receptor_Ig; 1.
DR   SMART; SM00060; FN3; 3.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          346..457
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          565..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  77260 MW;  CF315A20C2E5CAFD CRC64;
     VCKRGDVTVK PSHVISLGSA VNISCSLKPK QGCSHYSSLN KLILYKFDRR VSFHHGRSLS
     SQVTDLPLGT TLFVCKLSCI SSDEIRICGA EISVGVAPEQ PQNVSCIQKG EQGTVACTWD
     RGRDTHLYTE YTLQLSGPRN LTWQKQCKDY YCDHLDLGIN LTPESPESSF TAKVTAINSL
     GSSSSFPSTF TVLDIVRPLP PWDIRIEFQN ASASRCTLQW RDEGLVLLNR LRYRPRNSRS
     WNMPTGMLDV WYMKRHIDYN RQQISLFWKN LSVSEARGKI LHYRVTLQEV TVGKAPFRNI
     TGHTSWTWVA PRTGNWAVAV SAANSKGSSP PTRINITNLC EADLLAPLQV SADSGGVDNI
     VVTWQPPRKA PSAVEEYVLE WRELRAGGDT QPPLNWLRSP PYNVSALISE IPYRVSQNSH
     PINSLQPRVT YVLWMTALTA AGESSQGNER EFCLQGKANW KVFVAPSICI AIIMVGIFSM
     RYFRQKVFVL LLALRPQWCS KEIPDPANST WAKKYPIAEE RTRLPLDGLL TAWPSPEEPE
     PLVIHEVLHQ VTPVFRHPHQ PYWPEKGQGV QGHHSSEEDA VCSASSPSPP QALPAERRQL
     VGLYRVLGSR GPEAKPGNPA SPLTVLPVDY LPTHEGYLPS SLDEAPLSDP LGELEPQHVS
     LSVFPSSSFH PLTFSCGEKL TLGQLKMGCD SLML
//