ID A0A2K6FDQ3_PROCO Unreviewed; 1998 AA.
AC A0A2K6FDQ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Cytoskeleton associated protein 5 {ECO:0000313|Ensembl:ENSPCOP00000012088.1};
GN Name=CKAP5 {ECO:0000313|Ensembl:ENSPCOP00000012088.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000012088.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000012088.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
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DR RefSeq; XP_012500554.1; XM_012645100.1.
DR STRING; 379532.ENSPCOP00000012088; -.
DR Ensembl; ENSPCOT00000022680.1; ENSPCOP00000012088.1; ENSPCOG00000017517.1.
DR GeneID; 105811021; -.
DR KEGG; pcoq:105811021; -.
DR CTD; 9793; -.
DR GeneTree; ENSGT00390000014757; -.
DR OrthoDB; 5477703at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0035371; C:microtubule plus-end; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:Ensembl.
DR GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:Ensembl.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0090063; P:positive regulation of microtubule nucleation; IEA:Ensembl.
DR GO; GO:0007051; P:spindle organization; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 4.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..227
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 269..472
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 405..443
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 551..783
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 815..1047
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1156..1394
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 481..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1766..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1914..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1931..1946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 221928 MW; 3DB29EF3120CFD35 CRC64;
MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKFL GLIKKFVTDS
NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ PKAKAKELGI EICLMYIEIE
KGEAVQEELL KGLDNKNPKI VVACIETLRK ALSEFGSKII LLKPIIKVLP KLFESREKAI
RDEAKLIAVE IYRWIRDALR PPLQNINSVQ LKELEEEWVR LPTGAPKPSR FLRSQQELEA
KLELQQSAGG DAEGGGDDGD EVPQIDAYEL LEAVEVLSKL PKDFYDKIEA KKWQERKEAL
EAVEVLVKNP KLEAGDYADL VKALKKVVPT ILEKFKEKKP QVVQALQEAI DAIFLTTTLQ
NISEDVLAVM DNKNPTIKQQ TSLFIARSFR HCTASTLPKS LLKPFCAALL KHINDSAPEV
RDAAFEALGT ALKVVGEKAV NPFLADVDKL KLDKIKECSE KVELVHGKKA GLAADKKEFK
PVPGRTAASG AAGDKDMKDI SAPKPGPLKK APATKAGGPP KKGKPTAPGG TGSTGTKNKK
GLETKEIVEP ELSIEVCEEK ASVVLPPTCI QVLDSSNWKE RLACMEEFQK AVELMDRTEM
PCQALVRMLA KKPGWKETNF QVMQMKLHIV ALIAQKGNFS KTSAQIVLDG LVDKIGDVKC
GNNAKEAMTA IAEACMLPWT AEQVMSMAFS QKNPKNQSET LNWLSNAIKE FGFSGLNVKA
FISNVKTALA ATNPAVRTSA ITLLGVMYLY VGPSLRMFFE DEKPALLSQI DAEFEKMQGQ
SPPAPTRGIS KHSTSGTDEG EDGDEPDDGG NDVVDLLPRT EISDKITSEL VSKIGDKNWK
IRKEGLDEVA GIINEAKFIQ PNIGELPTAL KGRLNDSNKI LVQQTLNILQ QLAVAMGPNI
KQHVKNLGIP IITVLGDSKN NVRAAALATV NAWAEQTGMK EWLEGEDLSE ELKKENPFLR
QELLGWLAEK LPSLRSTPTD LILCVPHLYS CLEDRNGDVR KKAQDALPFF MMHLGYEKMA
KATGKLKPTS KDQVLAMLEK AKANMPAKPA APTKATSKPM GGSAPAKFQP ASAPAEDSVS
SSAEPRPDPK KAKAPGVSSK AKSAQGKKVP SKTSLKEDED KSGPIFIVVP NGKEQRMKDE
KGLKVLKWNF TTPRDEYIEQ LKTQMSSCVA KWLQDEMFHS DFQHHNKALA VMVDHLESEK
EGVIGCLDLI LKWLTLRFFD TNTSVLMKAL EYLKLLFTLL SEEEYHLTEN EASSFIPYLI
LKVGEPKDVI RKDVRAILNR MCLVYPASKM FPFIMEGTKS KNSKQRAECL EELGCLVESY
GMNVCQPTPG KALKEIAIHI GDRDNAVRNA ALNTIVTVYN VHGDQVFKLI GNLSEKDMSM
LEERIKRSAK RPSAAPIKQV EEKPQRTQSI SSNANMLRKG PAEDMSSKLN QARSMSGHPE
AAQMVRREFQ LDLDEIENDN GTVRCEMPEL VQHKLDDIFE PVLIPEPKIR AVSPHFDDMH
SNTASTINFI ISQVASGDIN TSIQALTQID EVLRQEDKAE AMSGHIDQFL IATFMQLRLI
YNTHMADEKL EKDEIIKLYS CIIGNMISLF QIESLAREAS TGVLKDLMHG LITLMLDSRI
EDLEEGQQVI RSVNLLVVKV LEKSDQTNIL SALLVLLQDS LLATASSPKF SELVMKCLWR
MVRLLPDTIN SINLDRILLD IHIFMKVFPK EKLKQCKSEF PIRTLKTLLH TLCKLKGPKI
LDHLTMIDNK NESELEAHLC RMMKHSMDQT GSKSDKETEK GASRLDEKSS KAKVNDFLAE
IFKKIGSKEN TKEGLAELYE YKKKYSDADI EPFLKNSSQF FQSYVERGLR VIEMEREGKG
RIPTSTGISP QMEVTCVPTP TSTVSSIGNT NGEEVGPSVY LERLKILRQR CGLDNAKQDD
RPPLTSLLSK PAVPTVASST DMLHSKLSQL RESREQHQHS DLDSNQIHSS GTMTTSSSST
ANIDDLKKRL ERIKSSRK
//
