ID A0A2K6FFL8_PROCO Unreviewed; 1092 AA.
AC A0A2K6FFL8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A8 {ECO:0000313|Ensembl:ENSPCOP00000012760.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000012760.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000012760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR RefSeq; XP_012509553.1; XM_012654099.1.
DR AlphaFoldDB; A0A2K6FFL8; -.
DR STRING; 379532.ENSPCOP00000012760; -.
DR Ensembl; ENSPCOT00000023362.1; ENSPCOP00000012760.1; ENSPCOG00000017965.1.
DR GeneID; 105818171; -.
DR KEGG; pcoq:105818171; -.
DR CTD; 9498; -.
DR GeneTree; ENSGT00940000157422; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032809; C:neuronal cell body membrane; IEA:Ensembl.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0140892; F:sodium,bicarbonate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0008510; F:sodium:bicarbonate symporter activity; IEA:Ensembl.
DR GO; GO:2000302; P:positive regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR GO; GO:0051453; P:regulation of intracellular pH; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF37; ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 478..500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 512..535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 555..579
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 591..609
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 693..711
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 731..749
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 779..798
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 819..843
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 879..898
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 905..924
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 956..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 144..402
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 449..957
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..76
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1092 AA; 122958 MW; D0349299342C25AB CRC64;
MPAGSNEPDG VLSYQRPDEE AVVDQGGTST ILNIHYEKEE LEGHRTLYVG VRMPLGRQSH
RHHRTHGQKH RRRGRGKGAS QGEEGLEPLA HDTPSQRVQF ILGTEEDEEH VPHELFTELD
EICVKEGEDA EWKETARWLK FEEDVEDGGE RWSKPYVATL SLHSLFELRS CLINGTVLLD
MRANSIEEIS DLILDQQELF SDLNDSTRVK VREALLKKHH HQNEKKRNNL IPIVRSFAEA
GKKQSDPHSM DKNGQTVSPQ SVLTTNLEVK NGVNCEHSPV DLSKVDLHFM KKIPTGAEAS
NVLVGEVDTL DRPIVAFVRL SPAVLLSGLT EVPIPTRFLF ILLGPVGKGQ QYHEIGRSMA
TIMTDEIFHD VAYKAKERDD LLAGIDEFLD QVTVLPPGEW DPSIRIEPPK NVPSQEKRKM
PGVPNGNICH IEPESHGGHS GPELQRTGRL FGGLVLDIKR KAPWYWSDYR DALSLQCLAS
FLFLYCACMS PVITFGGLLG EATEGRISAI ESLFGASMTG IAYSLFAGQA LTILGSTGPV
LVFEKILFKF CKDYALSYLS LRACIGLWTA FLCIVLVATD ASSLVCYITR FTEEAFASLI
CIIFIYEAIE KLIHLAETYP IHMHSQLDHL SLYYCRCTLP ENPNNHTLQY WKDHNIVTTE
IHWANLTVSE CQEMHGEFMG SACGHHGPYT PDVLFWSCIL FFTTFILSST LKTFKTSRYF
PTRVRSMVSD FAVFLTIFTM VIIDFLIGVP SPKLQVPSVF KPTRDDRGWI ISPIGPNPWW
TVIAAIIPAL LCTILIFMDQ QITAVIINRK EHKLKKGCGY HLDLLMVAIM LGVCSIMGLP
WFVAATVLSI THVNSLKLES ECSAPGEQPK FLGIREQRVT GLMIFVLMGC SVFMTAILKF
IPMPVLYGVF LYMGVSSLQG IQFFDRLKLF GMPAKHQPDF IYLRHVPLRK VHLFTLIQLT
CLLLLWVIKA SPAAIVFPMM VLALVFVRKV MDLCFSKREL SWLDDLMPES KKKKLDDAKK
KAKEEEEAEK MLEMGADKFP LESRKLLSSP GKNNSFRCDP SEINISDEMP KTTVWKALSM
NPGNTKEKSL FN
//
