ID   A0A2K6FGJ8_PROCO        Unreviewed;      2036 AA.
AC   A0A2K6FGJ8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Ral GTPase activating protein catalytic subunit alpha 1 {ECO:0000313|Ensembl:ENSPCOP00000013108.1};
GN   Name=RALGAPA1 {ECO:0000313|Ensembl:ENSPCOP00000013108.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013108.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000013108.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012513753.1; XM_012658299.1.
DR   Ensembl; ENSPCOT00000023711.1; ENSPCOP00000013108.1; ENSPCOG00000018136.1.
DR   GeneID; 105821560; -.
DR   CTD; 253959; -.
DR   GeneTree; ENSGT00950000183139; -.
DR   OrthoDB; 21929at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR046859; RGPA/RALGAPB_N.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   Pfam; PF20412; RALGAPB_N; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          1796..2004
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          342..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..753
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          986..1007
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..747
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        894..910
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2036 AA;  229893 MW;  93809CD2E93EEA75 CRC64;
     MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
     NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
     SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSA PQSEHGPRTL DNLINPPLNL
     QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL
     FSHFKKYYLP YIFPNICKEN SLYHPILDIP QMRPKPHYVM IKKDAETNEA IYCIKEPFIN
     ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE VLPKNIQRAA ASLVSREENK NDNADKADRT
     TEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL
     LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEEIVITSS NLPCIENVTD HDISMEEGEK
     REEENGTNIA DHVRNSSWAK NGSYQDALHN ASEEATEQNI RAGTQAVLQV FIINSSNIFL
     LEPANEIKNL LDEHTDMCKR ILNIYRYMVV QVSMDKKTWE QMLLVLLRVT ESVLKMPSQA
     FLQFQGKKNM TLAGRLAGPL FQTLIVAWIK ANLNVYISRE LWDDLLSVLS SLTYWEELAT
     EWSLTMETLT KVLARNLYSL DLSDLPLDKL SEQKQKKHKG KGVGHEFQKV SVDKSFSRGW
     SRDQPGQAPM RQRSATTTGS PGTEKARSIV RQKTVDIDDA QILPRSTRVR HFSQSEDTGN
     EVFGALSEEQ PLPRSSSTSD ILEPFTVERA KVNKEDMSPK LPPLNTDIGS SSANVPDLMD
     EFIAERLRSG NASTMTRRGS SPGSLEIPKD LPDILNKQNQ MRPVDDPGVP SEWTSPASAG
     SSDLISSDSH SDSFSAFQYD GRKFDNFGFG ADTGIVSSTD VDSGSGHHQS AEEQEVASLT
     TLHIDSETSS LNQQAFSAEV ATVTGSESAS TVQSPLGSRS QTPSPSTLNI DHMEQKDLQL
     DEKLHHSVLQ TPDDLEISEF PSECCSVMAG GTLTGWHADV ATVMWRRMLG ILGDVNAIMD
     PEIHAQVFDY LCELWQNLAK IRDNLGISTD NLTSPSPPVL IPPLRILTPW LFKATRLTDK
     YKQGKLHAYK LICNTMKRRQ DVSPNRDFLT HFYNIMHCGL LHIDQDIVNT IIKHCSPQFF
     SLGLPGATML IMDFIVAAGR VASSAFLNAP RVEAQVLLGS LVCFPNLYFE LPALHPNIPD
     IAVSQFTDVK ELIIKTVLSS ARDEPSGPAR CVALCSLGIW ICEELVHESH HPQIKEALNV
     ICVSLKFTNK TVAHVACNML HMLVHYVPRL QIYQPDSPLK IIQILIATIT HLLPSTEASS
     YEMDKRLVVS LLLCLLDWIM ALPLKTLLQP VHATGAENDK TEKSVLNCIY KVLHGCVYGA
     QCFSNPRYFP MSLSDLASVD YDPFMHLESL KEPEPLHSPD SERSSKLQPV TEVKTQMQQG
     LISIAARTVI THLVNHLGHY PMSGGPAMLT SQVCENHDNH YSESTELSPE LFESPNIQFF
     VLNNTTLVSC IQIRSEENMP GGGLSAGLAS ANSNVRIIVR DLSGKYSWDS AILYGPPPVS
     GLSEPIPFIL SLSHQEKPEE LPTSNECLQD ITAKDGLSLQ FKRFRETVPT WDTIRDEEDV
     LDELLQYLGV TSPECLQRTG ISLNIPAPQP VCISEKQEND VINAILKQHT EEKEFVEKHF
     NDLNMKAVEQ DEPTPQKPQS AFYYCRLLLS ILGMNSWDKR RSFHLLKKNE KLLRELRNLD
     SRQCRETHKI AVFYVAEGQE DKHSILTNTG GSQAYEDFVA GLGWEINLTN HCGFMGGLQK
     NKSTGLTTPY FATSTVEVIF HVSTRMPSDS DDSLTKKLRH LGNDEVHIVW SEHTRDYRRG
     IIPTEFGDVL IVIYPMKNHM FSIQIMKKPE VPFFGPLFDG AIVNGKVLPL MVRATAINAS
     RALKSLIPLY QNFYEERARY LQTIVQHHLE PTTFEDFAAQ VFSPAPYHHL PSDADH
//