ID A0A2K6FGL0_PROCO Unreviewed; 2495 AA.
AC A0A2K6FGL0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Ral GTPase activating protein catalytic subunit alpha 1 {ECO:0000313|Ensembl:ENSPCOP00000013116.1};
GN Name=RALGAPA1 {ECO:0000313|Ensembl:ENSPCOP00000013116.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013116.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000013116.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 379532.ENSPCOP00000013116; -.
DR Ensembl; ENSPCOT00000023719.1; ENSPCOP00000013116.1; ENSPCOG00000018136.1.
DR GeneTree; ENSGT00950000183139; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT DOMAIN 2254..2462
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 342..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2495 AA; 280702 MW; 354C509D1486E6B1 CRC64;
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSA PQSEHGPRTL DNLINPPLNL
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL
FSHFKKYYLP YIFPNICKEN SLYHPILDIP QMRPKPHYVM IKKDAETNEA IYCIKEPFIN
ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE VLPKNIQRAA ASLVSREENK NDNADKADRT
TEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEEIVITSS NLPCIENVTD HDISMEEGEK
REEENGTNIA DHVRNSSWAK NGSYQDALHN ASEEATEQNI RAGTQAVLQV FIINSSNIFL
LEPANEIKNL LDEHTDMCKR ILNIYRYMVV QVSMDKKTWE QMLLVLLRVT ESVLKMPSQA
FLQFQGKKNM TLAGRLAGPL FQTLIVAWIK ANLNVYISRE LWDDLLSVLS SLTYWEELAT
EWSLTMETLT KVLARNLYSL DLSDLPLDKL SEQKQKKHKG KGVGHEFQKV SVDKSFSRGW
SRDQPGQAPM RQRSATTTGS PGTEKARSIV RQKTVDIDDA QILPRSTRVR HFSQSEDTGN
EVFGALSEEQ PLPRSSSTSD ILEPFTVERA KGAVPVIDSS SRHAPSLQSS TEASSITRST
ESHISDTHSR ESSLEVGDSI YDHLCHLIGP VELADSAFEQ IQYIDLEGDD DLLSSLKEYF
KENQENNSKN EISKDSASQD VIIAVNRDER LSLDKVEYID QEIKSENRTS FVGTLENIQC
QKEPNSAVFV SNIAPNQSDN FIRTQTSEKS KQLNSDKQSS EPSSDSSCDK EKRKNLHRQT
ATELDACVDI TLVEKLQGMQ INEKITVPHV TRAKKTTLKA PVNRRMPHVI NTSKLSPTKR
SLSETVTHRA KIMKIATKKR NSVHVTFRPS TESVQFYNPL ENKEAPWKMR LRKLSGFSGS
SNSSTSNTHT SSDSGTELVK PGVYRPLDTV STASVSSKTM KESTEIPTTV LQKEGITSNQ
LGSRSTLRSS SHEAGLQQGS LGGVYKTVVH ALSKPKANVS PQRQNRMPPE APLRDLYSHV
MGYFGRKAAV NKEDMSPKLP PLNTDIGSSS ANVPDLMDEF IAERLRSGNA STMTRRGSSP
GSLEIPKDLP DILNKQNQMR PVDDPGVPSE WTSPASAGSS DLISSDSHSD SFSAFQYDGR
KFDNFGFGAD TGIVSSTDVD SGSGHHQSAE EQEVASLTTL HIDSETSSLN QQAFSAEVAT
VTGSESASTV QSPLGSRSQT PSPSTLNIDH MEQKDLQLDE KLHHSVLQTP DDLEISEFPS
ECCSVMAGGT LTGWHADVAT VMWRRMLGIL GDVNAIMDPE IHAQVFDYLC ELWQNLAKIR
DNLGISTDNL TSPSPPVLIP PLRILTPWLF KATRLTDKYK QGKLHAYKLI CNTMKRRQDV
SPNRDFLTHF YNIMHCGLLH IDQDIVNTII KHCSPQFFSL GLPGATMLIM DFIVAAGRVA
SSAFLNAPRV EAQVLLGSLV CFPNLYFELP ALHPNIPDIA VSQFTDVKEL IIKTVLSSAR
DEPSGPARCV ALCSLGIWIC EELVHESHHP QIKEALNVIC VSLKFTNKTV AHVACNMLHM
LVHYVPRLQI YQPDSPLKII QILIATITHL LPSTEASSYE MDKRLVVSLL LCLLDWIMAL
PLKTLLQPVH ATGAENDKTE KSVLNCIYKV LHGCVYGAQC FSNPRYFPMS LSDLASVDYD
PFMHLESLKE PEPLHSPDSE RSSKLQPVTE VKTQMQQGLI SIAARTVITH LVNHLGHYPM
SGGPAMLTSQ VCENHDNHYS ESTELSPELF ESPNIQFFVL NNTTLVSCIQ IRSEENMPGG
GLSAGLASAN SNVRIIVRDL SGKYSWDSAI LYGPPPVSGL SEPIPFILSL SHQEKPEELP
TSNECLQDIT AKDGLSLQFK RFRETVPTWD TIRDEEDVLD ELLQYLGVTS PECLQRTGIS
LNIPAPQPVC ISEKQENDVI NAILKQHTEE KEFVEKHFND LNMKAVEQDE PTPQKPQSAF
YYCRLLLSIL GMNSWDKRRS FHLLKKNEKL LRELRNLDSR QCRETHKIAV FYVAEGQEDK
HSILTNTGGS QAYEDFVAGL GWEINLTNHC GFMGGLQKNK STGLTTPYFA TSTVEVIFHV
STRMPSDSDD SLTKKLRHLG NDEVHIVWSE HTRDYRRGII PTEFGDVLIV IYPMKNHMFS
IQIMKKPEVP FFGPLFDGAI VNGKVLPLMV RATAINASRA LKSLIPLYQN FYEERARYLQ
TIVQHHLEPT TFEDFAAQVF SPAPYHHLPS DADHY
//
