ID A0A2K6FH24_PROCO Unreviewed; 375 AA.
AC A0A2K6FH24;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=TNF receptor superfamily member 25 {ECO:0000313|Ensembl:ENSPCOP00000013279.1};
GN Name=TNFRSF25 {ECO:0000313|Ensembl:ENSPCOP00000013279.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013279.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000013279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A2K6FH24; -.
DR Ensembl; ENSPCOT00000023882.1; ENSPCOP00000013279.1; ENSPCOG00000018243.1.
DR GeneTree; ENSGT00940000161888; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08815; Death_TNFRSF25_DR3; 1.
DR CDD; cd13420; TNFRSF25; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022329; TNFR_25.
DR InterPro; IPR034050; TNFRSF25_N.
DR PANTHER; PTHR47220; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR PANTHER; PTHR47220:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01972; TNFACTORR25.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..375
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014343922"
FT REPEAT 71..114
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 71..114
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 290..371
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 266..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 40165 MW; 0F26565231F836D1 CRC64;
MKPRPGGCAA AAALFLVLLG AQAQGSTPSP RCDCASDFQK SNGAFCCRGC PAGHYLEAPC
TKPCGISTCH PCPQGTFLAR DNHHNPHCTR CQACDEQASQ VALENCSAVA DTHCGCEPGW
FVECKVSQCS NSSPFHCRPC LDCGTLHRHT LLSCSSRDTD CGTCLPGFYE HSDGCVPCPT
STLGSCPEPC AAVCGWKQNE AGTEVLTPPA THLSPSDSAH TFLVLPDNSE VCTVQLAGNS
WTPGSPQTQE APRPQVTWCW DQLPNRALDP PPAPSPAPPA GSAAAALQPG SQLYDVMDAV
PARRWKEFVR TLGLREAEIE AVEVEIGRFR DQQYEMLKRW RQQQPAGLGA VYAALERMGL
DGCAEDLRSR LQRGP
//
