ID A0A2K6FHB7_PROCO Unreviewed; 2630 AA.
AC A0A2K6FHB7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=ROS1 {ECO:0000313|Ensembl:ENSPCOP00000013373.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013373.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000013373.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR STRING; 379532.ENSPCOP00000013373; -.
DR Ensembl; ENSPCOT00000023976.1; ENSPCOP00000013373.1; ENSPCOG00000018293.1.
DR GeneTree; ENSGT00940000160831; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0002066; P:columnar/cuboidal epithelial cell development; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0010966; P:regulation of phosphate transport; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 6.
DR CDD; cd05044; PTKc_c-ros; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF527; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 9.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000312};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2630
FT /note="Tyrosine-protein kinase receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014401927"
FT TRANSMEM 2144..2165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..187
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 188..276
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 881..991
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1229..1324
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1325..1432
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1839..1937
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1940..2033
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2227..2501
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 2568..2589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 2262
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 2630 AA; 294768 MW; ABB094EE79200F26 CRC64;
MKNIYWLNLK LVNFATLGCL WISLGQCTVL NNCLKSCVTN LGRQLDTGTP YNLSEPCIQG
CHFWNSVHQE NCALKCVMAD GKWKEELKNA DVPTAPFASS IGSHSVTLRW KSANISGVKY
IVQWKYAQLL GSWTYTETVS KPSYMAEPLH PFTTYVFRVV WIFTAQLQLY SPPSPSYRTH
PYGVPETAPF IRNIESSSPD TVEVSWAPPQ FPGGPILGYN LRLISKNQKL DSGTQRTSFQ
FYSTLPNTTY RFSVAAVNEV GEGPEAESSI TTPSPAVQEE EQWLFLSRKT SLRKRSLQHL
VDEAHCLQSD AVHHNVTGQC IREMIPWCEK KDPEFPEEXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXTPP SLIAPQKIVV DSYNGYVFYL LRDGIYRADL PVPSGREAQA MRIVESCTLK
DFAVKPQSKR IIYFNDTAQV FMSTFLDGSA SHLVLPHVPF ANVKSFTCEN NDFLVTDGKA
VFQQDALSFN EFIVGCDLSH IEEFGFGNLV IFGLSTQLHP LPGCPQELSV LFGSHQALVQ
WKPPALAIGA SECAIPRVVT GPSAWQNWTY EVKVSTQDLP EISHVFSNIS GTTLNVPELQ
SATKYKVSVR ASSPKGPGPW SEPSVGTTLV PATEPPFIMA VKEDGLWSKP LNSFGPGEFL
SSDIGNVSDM DWYNNSLYYS DMKGDIYVWL LNGTDISENY HIPNIAGAGA LAFEWLGHFL
YWAGKTYVIQ RQSVLTGHTD IVTHVKLLVN DMVVDSVGGY LYWTTLYSVE STRLNGESFL
ILQAQPCSVG DTIITEFAAW STSEISQNAL MYYSGRLFWI NGFRIITTQE IGQRTSVSVL
EAAKFNQFTI IQTSLKPLPG NFSFTPKVIP DSVQVSSFRI EGNASSFQVL WDAPPVVDWG
AVFYSVEFSA HSKFLASEQQ PLPVFTVEGL EPYALFNLSV TPYTYWGKGP KTSLSLRAPE
TVPSAPENPR IFALPSGKYH KKNEVVVEFR WDKPKHENGV LTRFEIFYQI SNQSDTNKTF
EDWIAVNVTP SVMSFQLEGM SPRCLVAFQV RVFTSKGPGP FSDIVKSTIS EINPFPYLIT
LLGNKIVFLD MDQNQVVWTF SGEREISAVG YTADDEMGYY AEGNSLFLLD VHNRSSSELL
RDALAFDITV ITIDWISRHL YFALKESQNG MQIFDVDLEH KVKYPRELKI CNRNSTIISF
SVYPLLSRLY WTEVSDLGYQ MSYYSIINHT LHRILQPTAT NHQNGRSQCS CNVTEFELSG
AMTIDTSDLE KPLIYFAKAQ EIWAMDLEGC QCWRVIMVPA VLAGKTLVSL TVDGEFIYWI
ITAKASTQIY QAKKRNGAIL SQVKTLRSKH ILAYSSFMQP FPDKAFLSLA SDIEEPTILN
ATNISLTIKL PLAKTNLTGY GITSPTPTYL VYYTEVNEKR NSSDLKYRML EFQDSIALIE
DLQPFSTYMI QIAVKNYYSD PLEHFPLGKE IWGKTKSGVP EAVWLINTTV RSDTSLIISW
RESHKPNGPK ESVRYQLAIL HLALIPETPL RQSEFPNERL TLLVTRLSGG NLYVLKVLAC
HSEEMWCAES HPVTVETFDT PEKPYTLVPE NTSLQLHWKA PSNVNLIRFW FELQKWKYSE
FYHTEASCSQ GPAYVCNITD LQPYTSYSVR VVVVYVTGEN STSLPESFKT QAGVPTKPGI
PKLLEGSKNS IQWEKAEDSG NRLMYYILEI RYVTSNDSQD LNLRWKMTFN GSCSSICTWK
SKNLKGIFQF RVVAANNLGF GEYSGISENI ILVGDGFGIP ETSFIFTIIV GIFLIVTIPL
TFVWHRRLKN QKPPKEGPAV LVNEDKEMAE LQGLAAGVGL ANACYAIHTL PTQEEIENLP
AFPREKLTLR LLLGSGAFGE VYEGTAVDIL GVGSGELKVA VKTLKKGSTD QEKIEFLKEA
HLMSKFNHPN ILKQLGVCLL NEPQYIILEL MEGGDLLTYL RKARMTTFHG PLLTLVDLVD
LCVDISKGCV YLEQMHFIHR DLAARNCLVS VKDYTSPSRI VKIGDFGLAR DIYKNDYYRK
RGEGLLPVRW MAPESLMDGI FTTQSDVWSF GILIWEILTL GHQPYPAHSN LDVLNYVQTG
GRLEPPRNCP DDLWNLMIHC WAQEPDQRPT FHRIQDQLQL FRNFSLNSVS QCRDEANTSG
VINEGFEGEG GNMICVNSSD VMSIALMETK NQEGLNYMVL ATECSQGEKN SEGLPGSQES
ESCGLRKEEK EPHADKDFCQ EKQVAYCPPG KPEGLNYACL AHSGCGDGSD
//
