ID   A0A2K6FHE5_PROCO        Unreviewed;       378 AA.
AC   A0A2K6FHE5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Biglycan {ECO:0000256|ARBA:ARBA00017012, ECO:0000256|PIRNR:PIRNR002490};
GN   Name=BGN {ECO:0000313|Ensembl:ENSPCOP00000013400.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013400.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000013400.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in collagen fiber assembly.
CC       {ECO:0000256|ARBA:ARBA00002214, ECO:0000256|PIRNR:PIRNR002490,
CC       ECO:0000256|RuleBase:RU364096}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490,
CC       ECO:0000256|RuleBase:RU364096}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class I subfamily. {ECO:0000256|ARBA:ARBA00009811,
CC       ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364096}.
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DR   AlphaFoldDB; A0A2K6FHE5; -.
DR   STRING; 379532.ENSPCOP00000013400; -.
DR   Ensembl; ENSPCOT00000024003.1; ENSPCOP00000013400.1; ENSPCOG00000018303.1.
DR   GeneTree; ENSGT00940000155311; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   GO; GO:0019955; F:cytokine binding; IEA:Ensembl.
DR   GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR   GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
DR   GO; GO:0061975; P:articular cartilage development; IEA:Ensembl.
DR   GO; GO:0060348; P:bone development; IEA:Ensembl.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR   PANTHER; PTHR45712; AGAP008170-PA; 1.
DR   PANTHER; PTHR45712:SF11; BIGLYCAN; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01462; LRRNT; 1.
DR   PIRSF; PIRSF002490; SLRP_I; 1.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR002490-1};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530,
KW   ECO:0000256|PIRNR:PIRNR002490};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364096}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|PIRNR:PIRNR002490,
FT                   ECO:0000256|RuleBase:RU364096"
FT   CHAIN           26..378
FT                   /note="Biglycan"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR002490,
FT                   ECO:0000256|RuleBase:RU364096"
FT                   /id="PRO_5014212250"
FT   DOMAIN          72..104
FT                   /note="LRRNT"
FT                   /evidence="ECO:0000259|SMART:SM00013"
FT   DISULFID        73..79
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT   DISULFID        77..86
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT   DISULFID        331..364
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
SQ   SEQUENCE   378 AA;  42487 MW;  40AD7CC591AEC211 CRC64;
     MPKGPHRATM RPLWLLASLL ALSQALPFEQ KGFWDFTLDD GLLMMNDEEA SGADTTSGIP
     DLDSLTPTFS SMCPFGCHCH LRVVQCSDLG LKSVPKEISP DTTLLDLQNN DITELRKDDF
     KGLQHLYALV LVNNKISKIH EKAFSPLRKL QKLYISKNNL VEIPPSLPGS LVELRIHDNR
     IRKVPKGVFS GLRSMNCIEM GGNPLENSGF EPGAFDGLKL NYLRISEAKL TGIPKDLPET
     LNELHLDHNK IQAIELEDLL RYSKLYRLGL GHNQIRMIEN GSLSFLPTLR ELHLDNNKLS
     RVPAGLPDLK LLQVVYLHSN NITKVGVNDF CPVGFGVKRA YYNGISLFNN PVPYWEVQPA
     TFRCVTDRLA IQFGNYKK
//