ID A0A2K6FHK6_PROCO Unreviewed; 2266 AA.
AC A0A2K6FHK6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Polycystin family receptor for egg jelly {ECO:0000313|Ensembl:ENSPCOP00000013458.1};
GN Name=PKDREJ {ECO:0000313|Ensembl:ENSPCOP00000013458.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013458.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000013458.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR STRING; 379532.ENSPCOP00000013458; -.
DR Ensembl; ENSPCOT00000024061.1; ENSPCOP00000013458.1; ENSPCOG00000018349.1.
DR GeneTree; ENSGT00940000162080; -.
DR OMA; KNHMWFS; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..2266
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014434870"
FT TRANSMEM 1192..1212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1397..1415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1435..1457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1588..1611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1623..1645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1720..1744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1978..1998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2010..2030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2050..2076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2097..2124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2159..2185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 222..920
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1237..1354
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1492..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1527..1542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1819..1836
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2266 AA; 257093 MW; D93C117C75C595B4 CRC64;
MRPGPALLLL GLGLGLGLLP PHPAPRGARA AVPGSGGLLR GARGLRERGG RTRLSLRRRA
ARDGGVLLSG SRDLCFPRGG PGRRRVSPRP PGWYCLGVRV LLRGRPGPAA PTHVDLRVSA
PRGRLSLAWS ARLPHSLGPL AWAFRLRLLG PGEARPTRAR RAAAATRPSA LSVLPADPRP
YSGFVAHTQC PTDGPTPVVL EAVDSSNRTA MTSSVSCQIR SCIIKQVKIN TNNDSAPVFL
TRKEEATINA TAQYDCPFAQ AIATYWQVFS VPSVNDVPDW TQPMDLSQIE IKNDPLFIHI
PRSSLHWGVY VFNFTVSITT SDPRMPLVQD SDSIYVCIVR RPLKAVILGN ASMTVNFTDE
LILNGAMSSD PEADDPLEGL QFFWHCTTNP HNYREDQIMV MNQEVCHPEQ TNLKWPWASG
PVLTLLPETL KGAQVYFFRM VIQKGFRRAF SDKRVHVLQG PRAIAHISCI ENCDRTLIIS
DRFSLFLNCT NCARRDFYKW SILSSLGSEV LFDWMGQTVT GRNSAYLSIK AFAFSHFSEA
EFSASLYVAS WSGDISVFRH FFIPNHGPQL GECKINPAKG IALFTKFVVQ CSNFKDQHIP
LTYKIIVSDL HGIGEISSVK ENSLGAILYL GTEPTAPPSF LPVGVLTNHY ATKIYAQVYD
SLGAFAQVTL YATVQAPTDK NSSKTVLHQL LDLTNGPSSL LSTLLQKQNF LSAGYLMYIV
ASVLNNMKAE LPLRAEKVNL REHLVNQSFL LPASTLVEIG QVVTTITKLT QKPLELTGVA
QKRATVRIWQ ANQALQEYQQ KDKHFSSEQI EIVSTGILTS LSNILKLTVP HEVVEDPFYV
IESLSDTILA NKVPGTETTV MRTPNFNMYV KKVEKWKVTQ VFRNETRCRN CFYPALNVSS
VPALPANAPV STMFCEFAED PFPWLDGGES ASVEVVGFRM TGAADNGTVI EITPDVVEVY
LVRKNLTFAA FNLTVGPSSE LDGALKKTTG VFSFEVDSRV LREVLVHIVT EVTVLFEVLV
YAGSQLSPTA LVATFLVPHD IPPVASQSAL FDPACTVKAA RLVCLPLSLL QVIAQRSHSS
QCAISVVLRA PRFVIKPNDR LVRISLFSVQ CLDMYGIQSE WREDNCVLGE KTTWHKVHCV
CRHAVRARRQ LGTLRLTSLH LHTCYVMARV IVVPNPVDLQ LKVIKNVYHN PVTLFTVLFI
MFLYMVLAFW ALHRDEMDQF LREHVIVLPD NDPYDNICYL VTVFTGSRCG AGTRADVFVQ
LRGTASTSDV HCLSHPHFTT LYRGSISTFL LTTKSDLGDI HSIRVWHNNE GKAPSWYLSR
IKVENLFSRH VWLFICRKWL SVDTTLDRTF HVTHPDQPLN RRDFFFIDVS NKLGKNHMWF
SIFASVVPKP FSRLQRLSCC LAMLLSSLLC NIMFFNLNRK EQTQSREGRY IRSMMIGIES
VLITIPVQLL ITFLFTYSQK KPQVKLEEVS PQEHPLMSED GGHWEERLGK WHARQTAVTH
ASETAKTVKP ASRRKPGIPK PSVKATFRSK HQHEKAETKA PETHRPNTNS NNNNNNREDN
EDVPSEEPSS QQDLAPPKKK PRIVLPWWCV YAAWFLVFAA SSISSFFIVF YGLTYGYERS
VEWLFACFCS FCQSVFLVQP SKIILWSGIR TNKPKYCKNL SWSTRYHYSE IRLRRMNMHP
EEMRRLHDRI SQIRGTRMYQ PLTEDEVRIF KRKKRIKRRA LLFLSYLATH LIFLALLLVL
IGLLRHTDSF YYNQFLRDQF SMDLAAVTKL EDVYRWLNSV LLPLLHNDLN PTFLLDGSST
ILGLPLMRQV RAKSTEKPCL PAENFVQNSI KREIRCHPKY GIDPEDTKDY SSFWNEIDKR
HTHKNTNGFA YKHQGKQWVY YSYGSLHTYG SGGYAFYFFP KQQKFNSTLR LRELQESNWL
DEKTWAVILE LTTFNPDVSL FCSISVVFEV SQLGVVNTSI ALYSFSLAEF NRKASAEIYL
YVAILIFFLA YTVDEGYIIM QERASYVRSV YNLLNFALKC IFTVLIVLFL RKHFLATGMI
RFYLSNPEDF IPFHAVSRVD HTMRIILGFL LFLTILKTLR YSRFFYDVRL AQKAIQAALP
GICHMAFVVS VYFFVYMAFG YLVFGQHEWN YSNLIHATQT IFSYCVSAFQ NTEFSHNRIL
GVLFLSSFML VMICILINLF QAVILSAYEE MKQPVYEEPS DEVEAMTYLC GKLRTIFGFQ
TSQSRAKDEP EFFVDMLYGQ PEKNNHRYLG LKTRNINGKK MVYLVV
//
