ID A0A2K6FIW6_PROCO Unreviewed; 460 AA.
AC A0A2K6FIW6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Solute carrier organic anion transporter family member 6A1 {ECO:0000313|Ensembl:ENSPCOP00000013908.1};
GN Name=SLCO6A1 {ECO:0000313|Ensembl:ENSPCOP00000013908.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000013908.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000013908.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657}.
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DR AlphaFoldDB; A0A2K6FIW6; -.
DR Ensembl; ENSPCOT00000024515.1; ENSPCOP00000013908.1; ENSPCOG00000018603.1.
DR GeneTree; ENSGT01080000257410; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF95; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 6A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..302
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50828 MW; 17ABDBB3F4E22EA2 CRC64;
MPRVAEGRHG PEQENPAKLE SEPAPARPAR GTRTGKVRET RKAEKAERKP LYLTNLPTAL
IKFGGFQKKG KTETPHITQK PAKAEVGSEE PCGLGCIVIP CCQMFNDIRV YMVFYCVLVM
SQGVMFGLVD LSVTNFQKDY ILKPIENFAL SFSYEVSSGL VAIFIAFYGE GNKKIKWIVV
SSLLMGFGSL LFALPFSNSR YDQWKVETEG IADASSTLGY ALGYVIGAPL VKASENSTSE
IKTGQLGDLT APCNEQCSCS SSVYSSVCGR DDIEYFSPCF AGCTYSKMLN KQKVYYNCSC
IKEGLIIADG EGEFIDARPG KCDAKCYKLP LFIAFVSSVI IFSGFSGVPL TMAIIRILPD
KLRSLALGMS FVTKRIFGSI PGPLAFQFSV ENSCTFRDIN KCGHTGRCWI YNKTRMAYLL
KCTEIKLFSK LIVVYSKRGS HTTPITMKKM KAKRKNKGKK
//
