ID   A0A2K6FJC9_PROCO        Unreviewed;       752 AA.
AC   A0A2K6FJC9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Rho guanine nucleotide exchange factor 4 {ECO:0008006|Google:ProtNLM};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000014084.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000014084.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6FJC9; -.
DR   STRING; 379532.ENSPCOP00000014084; -.
DR   Ensembl; ENSPCOT00000024691.1; ENSPCOP00000014084.1; ENSPCOG00000018711.1.
DR   GeneTree; ENSGT00940000160622; -.
DR   OMA; ACMRTQQ; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01224; PH_Collybistin_ASEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11973; SH3_ASEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR   PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          256..315
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          346..530
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          561..668
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..340
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   752 AA;  85358 MW;  EA0ADA9884EEE4F0 CRC64;
     MVSLGSYSDV DSSSGAPESP KIPKTRTSLL LSLQTINQAG QKEERGKRGQ RPRGLSTAPS
     LRDLPGSENH KPWEELLGEK PSCSCGQKAV HAEPAQGPGP TTERITWILP REAPVPPRSI
     AHCPPISLDD LWLEKMQRKK LEKQAQAEPR MQAGAAHRDG VQCWRKTIIT SAESLDLSRS
     SCPLSQSAPT GLNHVGWPEH IPDTAMPDGA LDAAMRADEA GSEEDLYEDL HGSGHHYSHP
     GGGGEQLAIN ELISDGSAVC AEALWDHVTM DDQELGFKAG DVIEVMDATN REWWWGRVAD
     GEGWFPASFV RLRVNQDEPG DDEAPRPGDG EARDSGTEAQ SSKDQMRTNV INEILSTERD
     YIKHLRDICE GYLRQCRKRA DMFSEEQLRT IFGNIEDIYR CQKAFVKALE QKFNRERPHL
     SELGACFLEH QADFQIYSEY CNNHPNACVE LSRLAKLSKY VYFFEACRLL QKMIDISLDG
     FLLTPVQKIC KYPLQLAELL KYTHPQHRDF KDVEAALHAM KNVAQLINER KRRLENIDKI
     AQWQSSIEDW EGEDLLVRSS ELIYSGELTR VTQPQAKSQQ RMFFLFDHQL IYCKKDLLRR
     DVLYYKGRLD MDGLEVVDLE DGKDRDLHVT VKNAFRLHCG TTGDSHLLCT RKPEQKQRWL
     KAFAREREQV RLDQETGFSI TELQRKQAML NASKQQATGK PKAVGRPCYL TRQKHPALPS
     SRPQPQVLVL AEPRRKPSTF WHSISRLAPF RK
//