ID   A0A2K6FJL3_PROCO        Unreviewed;       733 AA.
AC   A0A2K6FJL3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000014148.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000014148.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6FJL3; -.
DR   STRING; 379532.ENSPCOP00000014148; -.
DR   Ensembl; ENSPCOT00000024755.1; ENSPCOP00000014148.1; ENSPCOG00000018749.1.
DR   GeneTree; ENSGT00940000154342; -.
DR   OMA; LCLMCIC; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd21231; CH_DMD_rpt1; 1.
DR   CDD; cd21233; CH_DMD_rpt2; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 3.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF449; -; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF00435; Spectrin; 1.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00150; SPEC; 2.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 3.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
PE   4: Predicted;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          7..111
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          126..232
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          303..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          556..583
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   733 AA;  84652 MW;  BC9A4F8BA261DAB6 CRC64;
     MEDEREDVQK KTFTKWINAQ FSKYGKQHIE NLFSDLQDGR RLLDLLEGLT GQKLPKEKGS
     TRVHALNNVN KALRVLQNNN VDLVNIGSTD IVDGNHKLTL GLIWNIILHW QVKNVMKNIM
     AGLQQTNSEK ILLSWVRQST RNYPQVNVIN FTTSWSDGLA LNALIHSHRP DLFDWNSVVC
     QQSATQRLEH AFNIAKYQLG IEKLLDPEDV ATTYPDKKSI LMYITSLFQV LPQQVSIEAI
     QEVEMLPRPS KVTKEEHFQL HHQMHYSQQI TVSLAQGYER TPSSPKPRFK SYAYTQAAYV
     TTSDPTRSPF PSQHLEAPED KSFGSSLMET EVNLDRYQTA LEEVLSWLLS AEDTLQAQGE
     ISNDVEEVKE QFHTHEGYMM DLTAHQGRVG HVLQLGSQLI GTGKLSEDEE AEVQEQMNLL
     NSRWECLRVA SMEKQSNLHK VLMDLQNQKL KELNDWLTKT EERTRKMEEE PLGPDLEDLK
     RQIQQHKVLG DRWANICRWT EDRWVLLQDI LLKWQRFTEE QCLFSSWLSE KEDAVNKIPT
     TAFKDQDEML SSLRKLAVLK ADLERKKQSI DKLRSLNQDL LSTLKNKSVT QKMEAWLENF
     AKSWDNLSQK LEKSSAQISQ AVTTTQPSLT QTTVMETVTM VTTREQILVK HAQEELPPPP
     PQKKRQITVD SEIRKRLDVD ITELHSWITR SEAVLQSPEF AIYRKEGNFS DLKEKVNVGY
     ALIFLHVPIL YCL
//