ID   A0A2K6FJQ5_PROCO        Unreviewed;       307 AA.
AC   A0A2K6FJQ5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Sirtuin 3 {ECO:0000313|Ensembl:ENSPCOP00000014229.1};
GN   Name=SIRT3 {ECO:0000313|Ensembl:ENSPCOP00000014229.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000014229.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000014229.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
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DR   AlphaFoldDB; A0A2K6FJQ5; -.
DR   Ensembl; ENSPCOT00000024836.1; ENSPCOP00000014229.1; ENSPCOG00000018789.1.
DR   GeneTree; ENSGT00940000159464; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 2.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085:SF15; NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..307
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014427161"
FT   DOMAIN          80..307
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
SQ   SEQUENCE   307 AA;  33625 MW;  8C1A8134C0455B3C CRC64;
     MALWGRRAPL VLGLWGAGAG TRGLLGAHAG LAGPGVPRSM RLVVICYLCH SAFSVRITGG
     RRPISFSVGA SSVFGSRGNS EKGKLSLLDI AELIRARACQ RVVVMVGAGV STPSGIPDFR
     SPGSGLYSNL QQYDIPYPEA IFELSFFFHN PKPFFTLAKE LYPGNCRPNV THYFLRLLHD
     KGLLLRLYTQ NIDGLERVSG IPASKLVEAH GTFASATCTV CRRPFPGEDF WVEPFASLSE
     AVRSSVPRLL INRDLVGPLA WRPRSRDVAQ LGDVVHSVER LVELLGWTEE LQDLIQRETG
     KLDGRDK
//