ID   A0A2K6FKN5_PROCO        Unreviewed;       448 AA.
AC   A0A2K6FKN5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Tetratricopeptide repeat domain 8 {ECO:0000313|Ensembl:ENSPCOP00000014566.1};
GN   Name=TTC8 {ECO:0000313|Ensembl:ENSPCOP00000014566.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000014566.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000014566.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6FKN5; -.
DR   Ensembl; ENSPCOT00000025176.1; ENSPCOP00000014566.1; ENSPCOG00000018975.1.
DR   GeneTree; ENSGT00940000156816; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:1905515; P:non-motile cilium assembly; IEA:InterPro.
DR   CDD; cd21341; TTC8_N; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR028796; BBS8.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44177; TETRATRICOPEPTIDE REPEAT PROTEIN 8; 1.
DR   PANTHER; PTHR44177:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 8; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF13181; TPR_8; 3.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          293..326
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          364..397
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          35..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  50751 MW;  0EA925FE2E44AEB5 CRC64;
     MGSEMEPLLL AWSYFRRRKF QLCADLCTQM LEKSPYDQPG TSLKLPGSNQ TGGPSQAVRP
     ITQAGRPITG FLRPSTQSGR PGTMEQAIRT PRTAYTARPI TSSGRYVRLG TASMLTSPDG
     PFINLSRLNL TKYSQKPKLA KALDLAALST EHSQYKDWWW KVQIGKCYYR LGMYREAEKQ
     FKSALKQQEM VDTLLYLAKV YISLDQPMTA LNLFKRGLDK FPGEVTLLCG IARIYEEMNN
     SSAAAEYYKE VLKQDNTHVE AIACIGSNHF YSDQPEIALR FYRRLLQMGI YNCQLFNNLG
     LCCFYAQQYD MTLNSFERAL SLAENEEETA DVWYNLGHVA VGIGDTNLAH QCFRLALVNN
     NHHAEAYNNL AVLEMRKGHV EQARALLQTA SDLAPHIYEP HFNFATISDK IGDLQRSYVA
     AQKSEAAFPD HVDTQHLIKQ LKQHFAVL
//