ID   A0A2K6FLU9_PROCO        Unreviewed;      1419 AA.
AC   A0A2K6FLU9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Nischarin {ECO:0000313|Ensembl:ENSPCOP00000014946.1};
GN   Name=NISCH {ECO:0000313|Ensembl:ENSPCOP00000014946.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000014946.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000014946.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 379532.ENSPCOP00000014946; -.
DR   Ensembl; ENSPCOT00000025557.1; ENSPCOP00000014946.1; ENSPCOG00000019182.1.
DR   GeneTree; ENSGT00940000156494; -.
DR   OMA; WSKNDLC; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR   CDD; cd06875; PX_IRAS; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR037904; Nischarin_PX.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR15454:SF35; NISCHARIN; 1.
DR   PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          12..122
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          465..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1019..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..651
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..687
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1037..1054
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1419 AA;  158043 MW;  098C6178AF8664E5 CRC64;
     MAAAARSFGP EREAEPAKEA RVVGSELVDT YTVYIIQVTD GSHEWTVKHR YSDFHDLHEK
     LIAERKIDKN LLPPKKIIGK NSRSLVEKRE KDLEVYLQTL LAAFSGVAPR VLAHFLHFHF
     YEINGITAAL AEELFEKGEQ LLGAGEVFAI GPLQLYAVTE QLLQGKPTCT SGDAKTDLGH
     ILDFTCRLKY LKVSGTEGPF GTSNIQEQFL PFDLSIFKSL HQVEISHCDA KHIRGLVTSK
     PTLATMSIRF SATSMKEVLV PEALEFDEWE PEGTALEGPV TAVIPTWQAL TTLDLSHNSI
     SEIDESVKLI PKIEFLDLSH NGLLVVDNLQ HLYNLVHLDL SYNKLSSLEG VHTKLGNIKT
     LNLAGNLLES LSGLHKLYSL VNLDLCNNRI EQMEEVRSIG SLPCLEHVAL LNNPLSIIPD
     YRTKVLAQFG DRASEVCLDD TVTTEKELDT VEVLKAIQKA KEVKSKLSNP EKKVGEDSRL
     SAAACVRPGS SPPTVAPTSA SLPQPILSNQ GIMFVQEEAL ASSLSSTDSL TPEDRPIARG
     CSDSLESITA GQAASDELRD VPGAVGGASP EHAEPEVQVV PGSGQIIFLP FTCIGYTATN
     QDFIQRLSTL IRQAIERQLP AWIEAANQRE EGQGEQGEED DDEDEEEDVA ENRYFEMGPP
     DAEEEEEGGR GEEEEEEEED EEAEEERLAL EWALGADEDF LLEHIRILKV LWCFLIHVQG
     SIRQFAACLV LTDFGIAVFE IPHQESRGSS QHILSSLRFV FCFPHGDLTE FGFLMPELCL
     VLKVRHSENT LFIISDAANL HEFHVDLRSC FAPQHMAMLC SPILYGSHTS LQEFLRQLLT
     FYKVAGGCQE RSQGCFPVYL VYSDKRMVQT AAGDYSGNIE WASCTLCSAV RRSCCAPSEA
     VKSAAIPYWL LLTPQHLNVI KADFNPMPNR GTHNCRNRNS FKLSRVPLST VLLDPTRSCT
     QPRGAFADGH VLELLVGYRF VTAIFVLPHE KFHFLRIYNQ LRASLQDLKT VVIAKTPATG
     ASPQSPLADG QPAEGRGGPE LPPPQPVADP TPYPSPTPHL LSPISLQVEN EELRHLMWSS
     VVFYQTPGLE VTACVLLSTK AVYFVLHDGL RRYFSEPLQD FWHQKNTDYN NSPFHISQCF
     VLKLSDLQSV NVGLFDQYFR LTGSSPVQVV TCLTRDSYLT HCFLQHLMVV LSSLERTPSP
     EPVDKDFYSE FGNKTTGKME NYELIHSSRV KFTYPSEEEI GDLTFIVAQK LADPEKAPSL
     SILLYVQAFQ VGMPPPGRCR GPLRPKTLLL TSAEIFLLDE DYVHYPLPEF AKEPPQRDRY
     RLDDGRRVRD LDRVLMGYQT YPQALTLVFD DVQGHDLMGN VTLDHFGEVP GGLAGAGQGR
     EVQWQVFVPS AESREKLISL LARQWEALCG RELPVELTG
//