ID A0A2K6FPZ4_PROCO Unreviewed; 345 AA.
AC A0A2K6FPZ4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=UBA domain containing 2 {ECO:0000313|Ensembl:ENSPCOP00000016049.1};
GN Name=UBAC2 {ECO:0000313|Ensembl:ENSPCOP00000016049.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000016049.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000016049.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_012499906.1; XM_012644452.1.
DR AlphaFoldDB; A0A2K6FPZ4; -.
DR STRING; 379532.ENSPCOP00000016049; -.
DR Ensembl; ENSPCOT00000026671.1; ENSPCOP00000016049.1; ENSPCOG00000019777.1.
DR GeneID; 105810457; -.
DR KEGG; pcoq:105810457; -.
DR CTD; 337867; -.
DR GeneTree; ENSGT00950000182999; -.
DR OMA; ISGMCYS; -.
DR OrthoDB; 5401095at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1904153; P:negative regulation of retrograde protein transport, ER to cytosol; IEA:Ensembl.
DR GO; GO:0070972; P:protein localization to endoplasmic reticulum; IEA:Ensembl.
DR CDD; cd14305; UBA_UBAC2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041928; UBA_UBAC2.
DR PANTHER; PTHR43066; RHOMBOID-RELATED PROTEIN; 1.
DR PANTHER; PTHR43066:SF21; UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 305..345
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
SQ SEQUENCE 345 AA; 39145 MW; 15AAB39C90125FA0 CRC64;
MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKF FVYDLHAVKH DFQIWRLICG
RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW VLSALFDFIL VEMMHYSFGI
TAASNLPSGF LAPVFALFVP FYCSIPRVQV AQILGPLSIT NKTLIYILGL QLFTSGSYIW
IVAISGLISG MCYDSKMFQV HQVLCIPTWM AKFFSWTLEP IFSSSEPTGE ARIGMGATVD
IQRQQRMELL DRQLMFSQFA QGRQQRQPQG GMINWNRLFP PLRQRRNINY QDGRQSEQAA
SPPLEVSEEQ VARLMEMGFS RGDALEALRA SNNDLNVATN FLLQH
//
