ID A0A2K6FQC3_PROCO Unreviewed; 558 AA.
AC A0A2K6FQC3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Acyl-CoA synthetase short-chain family member 3, mitochondrial {ECO:0000256|ARBA:ARBA00040004};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.17 {ECO:0000256|ARBA:ARBA00012985};
DE AltName: Full=Acetate--CoA ligase 3 {ECO:0000256|ARBA:ARBA00042755};
DE AltName: Full=Propionate--CoA ligase {ECO:0000256|ARBA:ARBA00029726};
GN Name=ACSS3 {ECO:0000313|Ensembl:ENSPCOP00000016178.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000016178.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000016178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA;
CC Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392,
CC ChEBI:CHEBI:456215; EC=6.2.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate;
CC Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371,
CC ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036650};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173;
CC Evidence={ECO:0000256|ARBA:ARBA00036650};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR AlphaFoldDB; A0A2K6FQC3; -.
DR STRING; 379532.ENSPCOP00000016178; -.
DR Ensembl; ENSPCOT00000026800.1; ENSPCOP00000016178.1; ENSPCOG00000019847.1.
DR GeneTree; ENSGT00940000157479; -.
DR OMA; FIMGRTD; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT DOMAIN 62..116
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 123..347
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 442..520
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 558 AA; 60586 MW; 5A78F3C19C0823D7 CRC64;
MKPSWLQCRK VTGAGGLGGP LPGSSPARGA GAARRAFVAP GPWGGLGGRG CRALTSGSVG
EYKTHFAASV ADPERFWGQA AEQISWYKPW TKTLENRHPP STSWFVEGVL NICYNAIDRH
IENGKGDKIA IIYDSPVTNT KATITYKEVL EQVSKLAGVL VKHGIKKGDT VVIYMPMIPQ
AMYTMLACAR IGAIHSLIFG GFASKELSSR IDHVKVCALF GEIYSQLALK LYRHKGSFIL
IETVPLAPDR DLDWDEEMAK AQSHDCVPVL SEHPLYILYT SGTTGLPKGV VRPTGGYAVM
LNWTMSSIYG LKPGEVWWAA SDLGWVVGHS YICYGPLIHG NTTVLYETLE WSKKVFRVPV
LDHWWQTGEG GSGSSCLAAA SSKVEPTSRC AKDSGQGKGA PRLGYYDTMD AGYMDEEGYL
YVMSRVDDVI NVAGHRISAG AIEESVLSHG TVADCAVVGK EDPLKGHVPL ALCVLKKDIN
VTEEKVLEEI VKHVRQNIGP VAAFRNAVFV KQLPKTRSGK IPRSALSALV NGKPYKVTST
IEDPSIFGHI EEVLKQAL
//
