ID   A0A2K6FQZ4_PROCO        Unreviewed;       636 AA.
AC   A0A2K6FQZ4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Zinc finger SWIM-type containing 2 {ECO:0000313|Ensembl:ENSPCOP00000016382.1};
GN   Name=ZSWIM2 {ECO:0000313|Ensembl:ENSPCOP00000016382.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000016382.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000016382.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_012519096.1; XM_012663642.1.
DR   AlphaFoldDB; A0A2K6FQZ4; -.
DR   STRING; 379532.ENSPCOP00000016382; -.
DR   Ensembl; ENSPCOT00000027007.1; ENSPCOP00000016382.1; ENSPCOG00000019957.1.
DR   GeneID; 105825761; -.
DR   KEGG; pcoq:105825761; -.
DR   CTD; 151112; -.
DR   GeneTree; ENSGT00390000006826; -.
DR   OMA; RNQKWRS; -.
DR   OrthoDB; 140984at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   CDD; cd16486; mRING-H2-C3H2C2D_ZSWM2; 1.
DR   CDD; cd16494; RING-CH-C4HC3_ZSWM2; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR007527; Znf_SWIM.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   InterPro; IPR039903; Zswim2.
DR   PANTHER; PTHR21540:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2; 1.
DR   PANTHER; PTHR21540; RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF04434; SWIM; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   Pfam; PF00569; ZZ; 1.
DR   SMART; SM00184; RING; 2.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS50089; ZF_RING_2; 2.
DR   PROSITE; PS50966; ZF_SWIM; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00228}.
FT   DOMAIN          54..87
FT                   /note="SWIM-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50966"
FT   DOMAIN          147..199
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          230..281
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   DOMAIN          345..386
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          445..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  73388 MW;  A26345DCF78C0D99 CRC64;
     MLRRGHKASE RRRHLSESLS WQQDQALSSS IYLLREMGPT GFLLREEEPE NRDCRVFLGN
     PHVCNCSTFL KEGELCKHIC WILLKKFKLP RNHEFAFQLG LVEGEINDLL RGIHRVQSPQ
     PGTNDENAHI EEDGYIKQKE IGSEDICSIC QEVLLKNKLP VTFCRFGCGN SIHIKCMKIL
     ANYQNMTSNT SMLKCPLCRK EFAPLKLILE EFKNSSKLVT AAEKERLDKH LGIPCNNCKQ
     FPVEGKCYKC TECVEYHLCQ QCFDSGCHLS HIFTFREKRN QRWRLLEKGS DEVVKYIDIT
     NEIEKKMPHF QEKQGQVYTP KHIVKSLPLL LITKNSKLLT PGYQCRLCLK AFRLGQHTRL
     LPCAHRFHRK CIDSWLFHKC NSCPVDGQVI YNPLIWKNTT MNGQTQQSVS NIDIIHPSKQ
     EESKLFIPGT GLILKQNRHG ILPSISQRNS DKMNTPRSPT DTHQNITIDD LCSIKLDDSN
     SRKLIHEYKI SQHFPRYFQD LPTGSFGKIS SQTFLPSIDH KNIICHTGMK SPCISEKYHT
     GQSQKMTKGY KRINHNPEKT VGMKIREDNR RSNTLLPEDL NLIANWGTTQ LSMSKRHNNC
     MGKMKQKRTH LSRQPVSHSL NTKNTELSLI LEGVQL
//