ID   A0A2K6FR25_PROCO        Unreviewed;      1254 AA.
AC   A0A2K6FR25;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=DENN domain containing 5A {ECO:0000313|Ensembl:ENSPCOP00000016417.1};
GN   Name=DENND5A {ECO:0000313|Ensembl:ENSPCOP00000016417.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000016417.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000016417.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC       {ECO:0000256|ARBA:ARBA00006664}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR   AlphaFoldDB; A0A2K6FR25; -.
DR   Ensembl; ENSPCOT00000027044.1; ENSPCOP00000016417.1; ENSPCOG00000019972.1.
DR   GeneTree; ENSGT00940000153678; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   CDD; cd01757; PLAT_RAB6IP1; 1.
DR   CDD; cd17690; RUN1_DENND5A; 1.
DR   Gene3D; 1.20.58.900; -; 3.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR047278; DEN5A/B.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR047277; PLAT_RAB6IP1.
DR   InterPro; IPR047294; RUN1_DENND5A.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR   PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF02759; RUN; 2.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00593; RUN; 2.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   SUPFAM; SSF140741; RUN domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50095; PLAT; 1.
DR   PROSITE; PS50826; RUN; 2.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          34..575
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          764..927
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          931..1039
FT                   /note="PLAT"
FT                   /evidence="ECO:0000259|PROSITE:PS50095"
FT   DOMAIN          1101..1249
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          658..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        670..685
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1254 AA;  143257 MW;  9C230191F367B09F CRC64;
     MSGSGGGGGG SAPSRFADYF VICGLDTDTG LEPDELSGEN FEQTPLRRTF KSKVLARYPE
     NVEWNPFDQD AVGMLCMPKG LAFKTQADPR EPQFHAFIIT REDGSRTFGF ALTFYEEVTS
     KQICSAMQTL YHMHNAEYDV LHAPPADGRD QSGMEDGEGT PVTKLQRFNS YDISRDTLYV
     SKCICLITPM SFMKACRSVL EQLHQAVTSP QPPPLPLESY IYNVLYEVPL PPPGRSLKFS
     GVYGPIICQR PSTNELPLFD FPVKEVFELL GVENVFQLFT CALLEFQILL YSQHYQRLMT
     VAETITALMF PFQWQHVYVP ILPASLLHFL DAPVPYLMGL HSNGLDDRSK LELPQEANLC
     FVDIDNHFIE LPEDLPQFPN KLEFVQEVSE ILMAFGIPPE GNLHCSESAS KLKRLRASEF
     VSDKRNGNIA GSPLHSYELL KENETIARLQ ALVKRTGVSL EKLEVRDDPS SNKDLKVQCD
     EEELRIYQLN IQIREVFANR FTQMFADYEV FVIQPSQDKE SWFTNREQMQ NFDKASFLSD
     QPEPYLPFLS RFLETQMFAS FVDNKIMCHD DDDKDPVLRV FDSRVDKIRL LNVRTPTLRT
     SMYQKCTTVD EAEKAIELRL AKIDHTAVHP HLLDMKIGQG KYEPGFFPKL QSDVLSTGPA
     SNKWTKRNAP AQWRRKDRQK QHTEHLRLDN DQREKYIQEA RTMGSTIRQP KLSNLSPSVI
     AQTNWKFVEG LLKECRNKTK RMLVEKMGRE AVELGHGEVN ITGVEENTLI ASLCDLLERI
     WSHGLQVKQG KSALWSHLLH YQENRQRKLT SGSFSTSGIL LDSERRKSDA SSVMPPLRIS
     LIQDMRHIQN IGEIKTDVGK ARAWVRLSME KKLLSRHLKQ LLSDHELTKK LYKRYAFLRC
     DDEKEQFLYH LLSFNAVDYF CFTNVFTTIL IPYHILIVPS KKLGGSMFTA NPWICISGEL
     GETQILQIPR NVLEMTFECQ NLGKLTTVQI GHDNSGLYAK WLVEYVMVRN EIIGHTYKFP
     CGRWLGKGMD DGSLERILVG ELLTSQPEVD ERPCRTPPLQ QSPSVIRRLV TISPNNKPSK
     WEEGLGPHAD LSEPSCGSSL TLLLCGECGL VSALEQAFQH GFKSPRLFKN VFIWDFLEKA
     QTYYETLEQN EVVPEENWHT RARNFCRFVT AINNTPRNIG KDGKFQMLVC LGARDHLLHH
     WIALLADCPI TAHMYEDVAL IKDHTLVNSL IRVLQTLQEF NITLETSLVK GIDI
//