ID A0A2K6FTY0_PROCO Unreviewed; 1270 AA.
AC A0A2K6FTY0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Nuclear receptor coactivator 1 {ECO:0000313|Ensembl:ENSPCOP00000017438.1};
GN Name=NCOA1 {ECO:0000313|Ensembl:ENSPCOP00000017438.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000017438.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000017438.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR AlphaFoldDB; A0A2K6FTY0; -.
DR STRING; 379532.ENSPCOP00000017438; -.
DR Ensembl; ENSPCOT00000028075.1; ENSPCOP00000017438.1; ENSPCOG00000020541.1.
DR GeneTree; ENSGT00950000183021; -.
DR OMA; AQHVNIG; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IEA:Ensembl.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:Ensembl.
DR GO; GO:1904017; P:cellular response to Thyroglobulin triiodothyronine; IEA:Ensembl.
DR GO; GO:0060713; P:labyrinthine layer morphogenesis; IEA:Ensembl.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0000435; P:positive regulation of transcription from RNA polymerase II promoter by galactose; IEA:Ensembl.
DR GO; GO:0002155; P:regulation of thyroid hormone mediated signaling pathway; IEA:Ensembl.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 18..89
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 227..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1006
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 137477 MW; AFDA369884452A4A CRC64;
DDVQKSDISS SSQGVIEKES LGPLLLEALD GFFFVVNCEG RIVFVSENVT SYLGYNQEEL
MNTSVYSILH VGDHAEFVKN LLPKSLVRPP WPPRELGLQS CLICIARRLP RPPAITGVES
FMTKQDTTGK IISIDTSSLR AAGRTGWEDL VRKCIYAFFQ PQGREPSYAR QLFQEVMTRG
TASSPSYRFI LNDGTMLSAH TKCKLCYPQS PDMQPFIMGI HIIDREHSGL SPQDDTNSGM
SIPRVNPSVN PNISPAHGVA RSSTLPPSNS NMVSTRVNRQ QSSELHSSTH SNSSNSQGSF
GCSPGNQIVA NVALNQGQAS SQSSNPSLNL SNSPMEGTGI SLAQFMSPRR QVTSGLATRP
RMPNSSFPPN ISTLSSPVGM TGSACNNSNR SYSNIPVTSL QGMNEGPNNS VGFSASSPVL
RQISSQNSPS RLNIQPAKAE SKDNKEITTI LNEMIQSDNS SSDGKPLDSG LVHNNDRLSD
GDSKYSQTSH KLVQLLTTTA EQQLRHADID ASCKDVLSCT GTSNSASANS SGGSCPSSHS
SLTERHKILH RLLQEGSPSD ITTLSVEPDK KDSASTSVSV TGQAQGNSSI KLELDASKKK
ESKDHQLLRY LLDKDEKDLR STPNLSLDDV KVKVEKKEQM DPCNTNPTPM TNPKPAPEEI
KLESQNQFTA DLDQFDQLLP TLEKAAQLPG LCETDRMDGA VTNVAIKSEI LPASLQSTTA
RPTSRLNRLP ELELEAIDNQ FGQPGAGDQV PWTNNTMTAV NQNKPEDQCI SSQLDELLCP
PTTVEGRNDE KALLEQLVSF LSGKDETELA ELDRALGIDK LVQGGGLDVL SERFPPQQAT
PPLMMEERPN LYSQPYSSPS PTANLPSPFQ GMVRQKPSLG TMPVQVTPPR GAFSPGMGMQ
PRQTLNRPPA APNQLRLQLQ QRLQGQQQVS PPLNAQMLAQ RQRELYSQQH RQRQLIQQQR
AMLMRQQSFG NNLPPSSGLP VQMGTPRLPQ GAPQQFPYPP NYGTNPGTPP ASTSPFSQLA
ANPEASLANR NSMVNRGMTG NMGGQFGTGI NPQMQQNVFQ YPGSGMVPQG EANFAPSLSP
GSSMVPMPIP PPQSSLLQQT PPASGYQSPD MKAWQQGAIG NNNVFSQAVQ NQPTPAQPGV
YNNMSITVSM AGGNTNVQNM NPMMGQMQMS SLQMPGMNPV CPEQINDPAL RHTGLYCNQL
SSTDLLKTEA DGTQQVQQVQ VFADVQCTVN LVGGDPYLNQ PGPLGTQKPT SGPQTPQAQQ
KSLLQQLLTE
//
