ID A0A2K6FX83_PROCO Unreviewed; 702 AA.
AC A0A2K6FX83;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=SH2 domain containing 3C {ECO:0000313|Ensembl:ENSPCOP00000018596.1};
GN Name=SH2D3C {ECO:0000313|Ensembl:ENSPCOP00000018596.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000018596.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000018596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6FX83; -.
DR Ensembl; ENSPCOT00000029239.1; ENSPCOP00000018596.1; ENSPCOG00000021191.1.
DR GeneTree; ENSGT00940000154130; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 62..161
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 428..696
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 180..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 77135 MW; A378CB02CA49BFF7 CRC64;
MTERCSLWSA LSAAACCFYR GSFVQVQFSK EKYILDSSPE KLHKELEEEL KLSSTDLRSH
AWYHGRIPRE VSETLVQRNG DFLIRDSLTS LGDYVLTCRW RNQALHFKIN KVVVKAGESY
THIQYLFEQE SFDHVPALVR YHVGSRKAVS EQSGAIIYCP VNRTFPLRYL EASYGLGQGS
GKAASPASPS GPKGSHMKRR SVTMTDGLTA DKVTRSDGCS TSTSLPHPRD SIRSCALSMD
QIPDLHSPMS PISESPSSPA YSTVTRVHAT PAAPSATALP ASPVTRRSSE PQLCPGSAPK
PPGELDKGPH ASPSHTLCKA SPSPSLSSYS DPDSGHYCQL QPPVHGSREW AAAEASSRQA
KSYGEKLKEL SENGAPEGDW GKTFTVPIVE ATSSFNPATF QSLLIPKDNR PLEVGLLRKV
KELLTEVDAR TLARHVTKVD CLVARILGVT KEMQTLMGVR WGMELLTLPH GRQLRLDLLE
RFHTMSIMLA VDILGCTGSA EERAALLHKT IQLAAELRGT MGNMFSFAAV MGALDMAQIS
RLEQTWVTLR QRHTEGAILY EKKLKPFLKS LNEGKEGPPL SNTTFPHVLP LITLLECDSA
PAEGPEPWGS TEHGVEVVLA HLEAARTVAH HGGLYHTNAE VKLQGFQARP ELLEVFSTEF
QMRLLWGSQG ASSSQARRYE KFDKVLTALS HKLEPAVRSS EL
//
