ID   A0A2K6FYE7_PROCO        Unreviewed;       471 AA.
AC   A0A2K6FYE7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSPCOP00000019009.1};
GN   Name=KLKB1 {ECO:0000313|Ensembl:ENSPCOP00000019009.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000019009.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000019009.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6FYE7; -.
DR   Ensembl; ENSPCOT00000029656.1; ENSPCOP00000019009.1; ENSPCOG00000021434.1.
DR   GeneTree; ENSGT00940000161669; -.
DR   OMA; TAMYTPN; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd01100; APPLE_Factor_XI_like; 3.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR003609; Pan_app.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR   PANTHER; PTHR24252:SF14; TRANSMEMBRANE PROTEASE SERINE 3-LIKE; 1.
DR   Pfam; PF00024; PAN_1; 3.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00005; APPLEDOMAIN.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00223; APPLE; 3.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS00495; APPLE; 1.
DR   PROSITE; PS50948; PAN; 2.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          73..156
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          231..314
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          330..471
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   471 AA;  51951 MW;  8D6BD05EF8B3086A CRC64;
     VYTPSAQHCQ MVCTFHAKCL LFSFLPASST KEAGKRFGCF LKDSVTGTLP RVHRTNAISG
     HSLKQCGHQI SACHRDIYKG IDMRGANVNV SKVNSVEECQ KWCTNNIHCQ FFTYATQTFH
     NAEYRNNCLL KQSSSGTPTS IKVVDNVVSG FSLKPCALSE IGNCVTTIFH WRVACPSCYC
     CLRQLQCYIT TINVCFLKTS RSGTPSSPTP QENTISGYSL LTCKRTLPEP CHSKIYSGVD
     FGGEDLKVTF VNGVNVCQET CTKMIRCQFF TYSLLPEDCT GEKCKCSLRL SLDGSPTSIT
     YGTQGRSGYS LRLCEAGDSS VCTTKTNARI VGGTNSSWGE WPWQVSLQVQ LGARRHMCGG
     SIIGQQWVLT AAHCFIGLPL PDVWRIYSGI LSLSDITKET PVSLIKEIIV HQNYKSSEGG
     YDIALIKLHA PLNYTEFQKP ICLPSKGDIN TIYTNCWVTG WGFSEEKGTL G
//