ID A0A2K6FYY6_PROCO Unreviewed; 315 AA.
AC A0A2K6FYY6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=NK1 homeobox 2 {ECO:0000313|Ensembl:ENSPCOP00000019197.1};
GN Name=NKX1-2 {ECO:0000313|Ensembl:ENSPCOP00000019197.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000019197.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000019197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_012497862.1; XM_012642408.1.
DR AlphaFoldDB; A0A2K6FYY6; -.
DR Ensembl; ENSPCOT00000029845.1; ENSPCOP00000019197.1; ENSPCOG00000021546.1.
DR GeneID; 105808692; -.
DR KEGG; pcoq:105808692; -.
DR CTD; 390010; -.
DR GeneTree; ENSGT00940000162535; -.
DR OMA; IHHKISF; -.
DR OrthoDB; 679932at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24340; HOMEOBOX PROTEIN NKX; 1.
DR PANTHER; PTHR24340:SF17; NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT DOMAIN 161..221
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 163..222
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 47..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 32386 MW; DBE127B3CE03E392 CRC64;
MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR LAPREAKKSL AEVEAGKDAS
PGDLGRQRET PDAAGRGAGP ASPLEGSEAE EEEEDAEDAG RQQQLERAAC LLGGPARSPE
ALAGALAAGE SGADGEGGPV GSPGSPGSPR PRRRRAEPNC AKPRRARTAF TYEQLVALEN
KFRATRYLSV CERLNLALSL SLTETQVKIW FQNRRTKWKK QNPGADGAAQ AGGGAPQPGT
PGAAAGTCGG GGGGAGGSPG PPGPGILSFQ TFPSYSANVL FPAAASFPLT AASARSPFAP
FLGPSYLTPF YAPHL
//
