ID A0A2K6FZW0_PROCO Unreviewed; 153 AA.
AC A0A2K6FZW0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Myelin and lymphocyte protein {ECO:0000256|ARBA:ARBA00039981};
GN Name=MAL {ECO:0000313|Ensembl:ENSPCOP00000019501.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000019501.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000019501.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000256|ARBA:ARBA00034721}.
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DR RefSeq; XP_012497352.1; XM_012641898.1.
DR AlphaFoldDB; A0A2K6FZW0; -.
DR STRING; 379532.ENSPCOP00000019501; -.
DR Ensembl; ENSPCOT00000030151.1; ENSPCOP00000019501.1; ENSPCOG00000021698.1.
DR GeneID; 105808297; -.
DR KEGG; pcoq:105808297; -.
DR CTD; 4118; -.
DR GeneTree; ENSGT00940000154987; -.
DR OMA; FPDIFFI; -.
DR OrthoDB; 4214465at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0120003; C:hinge region between urothelial plaques of apical plasma membrane; IEA:Ensembl.
DR GO; GO:0044853; C:plasma membrane raft; IEA:Ensembl.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IEA:Ensembl.
DR GO; GO:0022010; P:central nervous system myelination; IEA:Ensembl.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0098737; P:protein insertion into plasma membrane; IEA:Ensembl.
DR GO; GO:0002175; P:protein localization to paranode region of axon; IEA:Ensembl.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR PANTHER; PTHR22776; MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR22776:SF12; MYELIN AND LYMPHOCYTE PROTEIN; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..151
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
SQ SEQUENCE 153 AA; 16675 MW; 63B2D75EE9382179 CRC64;
MAPAAASGGS TLPSGFSVFT TFPDFLFVLE FVFGGLVWIL IASSLVPIPL VQGWVMFVSV
FCFVATTALL ILYIIGAHGG ETSWVTLDAA YHCIASLFYL SASVLEALAT IYMQDGFTFK
YYHENISAVV FAYVATLLYV VHAVFSLIRW KSS
//
