ID A0A2K6G180_PROCO Unreviewed; 2759 AA.
AC A0A2K6G180;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=MAX dimerization protein MGA {ECO:0000313|Ensembl:ENSPCOP00000019997.1};
GN Name=MGA {ECO:0000313|Ensembl:ENSPCOP00000019997.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000019997.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000019997.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR Ensembl; ENSPCOT00000030648.1; ENSPCOP00000019997.1; ENSPCOG00000021953.1.
DR GeneTree; ENSGT00940000156269; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18911; bHLHzip_MGA; 1.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR037935; MAX_gene-associated_bHLHzip.
DR InterPro; IPR032060; MGA_dom.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF32; MAX GENE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF16059; MGA_dom; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 78..259
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 2116..2167
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 258..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1833..1857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2064..2097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2227..2288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2633..2676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1113..1147
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 261..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1662..1688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1972..1990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2006
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2076..2094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2238..2254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2270..2288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2759 AA; 304582 MW; FC14E43539BF90F8 CRC64;
MEEKQIILAN QDGGTVAGAA PTFFVILKQP GNGKTDQGIL VTNRDACALA SSVSSPGKSK
GKICLPADCT VGGITVTLDN NSMWNEFYHR STEMILTKQG RRMFPYCRYW ITGLDSNLKY
ILVMDISPVD NHRYKWNGRW WEPSGKAEPH VLGRVFIHPE SPSTGHYWMH QPVSFYKLKL
TNNTLDQEGH IILHSMHRYL PRLHLVPAEK ATEVIQLNGP GVHTFTFPQT EFFAVTAYQN
IQITQLKIDY NPFAKGFRDD GLNSKPQRDG KQKNSSDQEG NSVPSSPGHR VRLTEGEGSQ
IQPGDLDPIS RGHETSGKSL EKTSLNIKRD FLGFMDNDSA LEVPQLKQEV SESLVANNFE
DGSCIDSPLD PNGSFNVVIK EEPLDDYDYE VGECPEGITV KQEETDEETD VYSNSDDDPI
LEKQLKRHNK VDNLEADHLS PNWLPSSPSG VAKAKMFKLD SGKMPVVYLE PCAVTKSTVK
ISELPDNMLS ASRKDKSMLT ELEYLPTYIE NSSGTGFCLG KESENGLRRH SPDLRVVQKY
PFLKEPQWKY PDISDSISTE RILDSSKDST GDSLSEKEDL GRKRTTMLKI AAAPKAVSVN
QNAPPNVSGK RGRPRKLKLS KAGRPPKNTG KSLTATKNTP VGPGSTFPDV KPDLEDVDGV
LFVSFESKEA LDIHAVDGTT EEPSSLQAST TNDPGCRARI SQLEKELIED LKSLRHKQVI
HPGLQEVGLK LNSVDPTMSI DLKYLGVQLP LAPATSFPFW NLTGTNPASP DAGFPFVSRT
GKTNDFTKIK GWRGKFHSAS ASRNEGGNSE SSLKNRSAFC SDKLDEYLEN EGKLMETSMG
FSANAPTSPV VYQLPTKSTS YVRTLDSVLK KQSIISPSTS YSLKPHSVPA ASRKAKSQNK
QATFSGRTKS SYKSILPYSI SPKQKHSHMI LGDKVTKNFS STVSENQVNN FVVPTLDENV
FPKQISLRQA QQQQQQQQQG TRPPGLSKSQ VKLMDLEDCA LWEGKPRTYI TEERADVSLT
TLLTAQASLK TKPIHTIIRK RAPPCNNDFC RLGCVCSSLA LEKRQPTHCR RPDCMFGCTC
LKRKVVLVKG GSKTKHFQRK SAHRDPVFYD TLGEETREEE EGVREEEEQL KEKKKRKKLE
YTICEAEPEQ PVRHYPLWVK VEGEVDPEPV YIPTPSVIEP IKPLLLPQPE VLSTTVKGKL
LTGIKPARAY TPKSNPAIRE EDKDPVYLYF ESMMTCARVR VYERKKEEQR QPSPSPSPSP
SFQQQSSCHS SPENCTVKEP DSEQQPLRQL TCDLEDDSDK SQEKSWKSSC NEGESSSTSY
MHQRSPGGPT KLIEIISDCN WEEDRNKILS ILSQHINSNM PQSLKVGSFI IELASQRKSR
GEKNPPVYSS RVKISMPSCQ DQDDMAEKSG SETPDGPLSP GKMDDISPVQ TDALDSVRER
LHGGKGLPFY AGLSPAGKLV AYKRKPSSST SGLIQVASNA KVAASRKPRT LLPSTSNSKM
ASSSGTTTNR PGKNLKAFVP AKRPIGSVVG IRLPAPSKPS ETPPSSTSSS AFSVMNPVIQ
AVGSSAVNVI TQAPSLLSSG PNFVSQAGTL TLRISPPEPQ SFASKTGSET KITYSSGGQP
VGTASLIPLQ SGSFALLQLP GQKPVPSSIL QHVASLQMKR ESQNADQKDE TKSIKREQET
KKALHSEGQA IDPEANIIKQ NSGAIFSEET LNDSLEHGGD HLDEESLTEV VSATVKPAEH
SYITGSHTDE DCKDVNEECG TRNHNSSKEK LTILEVRTIS EKASNKTVQN VSKVQLQKLG
EVKVEQQKGL DNLEEKSNEF PVISKERSKL EFSGSKVVEQ QSNPQPEAKE KGCGDSLEKH
SIRERWRKHL KGPLTRKCVR TSQECKKEAD EQLIKETKTC QENSDVFQQE QGISDLLGKS
GTTENARVLK MECDSWSRIS NPPAFSIVPR RATKGSRGNG HFQGHLLLPG EQIKLKQEKK
GRRSSADFTV LDLEEDDEQD ENEKTDDSID EIVDVVSDYQ SEEVDDVEKN NCVEYIEDDE
EQVDIETVEE LSEEINVAHM KTTAAHTQSF KQPCRTHSST DEKTAERSRK TPPVPLKLKP
DYWSDKLQKE AEAFAYYRRT HTANERRRRG EMRDLFEKLK TTLGLLHSSK VSKSLILTRA
FSEIQGLTDQ ADKLIGQKNL LTRKRNILIR KVSSLSGKTE EVVLKKLEYI YAKQQALEAQ
KRKKKMGSDE FDVSHRSSKQ QEGSSASSVD LGQMFINNRR GKPLILSRKR DQATENTSPS
NTPHTSANLV MTPQGQLLTL KGPLFSGPVV TVSPGLLETD LKPQVGSSAM AQSENDDLFM
MPRIVNVTSL ATDGGLVDMG GSKYPHEVPD GKPPDHLTDT IRNEDNSLED LGRISSRGNH
RDGRMTLGPT QVFLANKDSG FPQIVDVSSM QEAQEFLPKK ISGDIRGIQY KWKENESRGE
RLKSKESSFH KLKMKDLKDS SIEMELRKVT SAIEEAALDS SELLTNMEDE DDTDETLTSL
LNEIAFLNQQ LNDDSVSLAE LPSTVDTEFP GDARRGFISK LPPGNSAAFQ VGHLGTGLKE
LPDVQGESDS TSPLLLHLED DDFSENEKQL AEPASEPDVL KIVIDSEIKD SLLSHRKTSD
GGKSTSDLPA EPESVSSPPL LHMRTGLENS SSTDTLWRPM PKLAPLGLKV ANPCNDADGQ
SLKVMPCLAP IAGKVGSVGH KMNLTGSDQE GRESKVMPTL APVVAKLGNS GASPSSAGK
//
