ID A0A2K6G299_PROCO Unreviewed; 1883 AA.
AC A0A2K6G299;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dedicator of cytokinesis 1 {ECO:0000313|Ensembl:ENSPCOP00000020346.1};
GN Name=DOCK1 {ECO:0000313|Ensembl:ENSPCOP00000020346.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000020346.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000020346.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_012510818.1; XM_012655364.1.
DR STRING; 379532.ENSPCOP00000020346; -.
DR Ensembl; ENSPCOT00000030999.1; ENSPCOP00000020346.1; ENSPCOG00000022132.1.
DR GeneID; 105819174; -.
DR KEGG; pcoq:105819174; -.
DR CTD; 1793; -.
DR GeneTree; ENSGT00940000154974; -.
DR OMA; LWDNQAF; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08694; C2_Dock-A; 1.
DR CDD; cd11707; DHR2_DOCK1; 1.
DR CDD; cd12051; SH3_DOCK1_5_A; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR047025; DOCK1_5_SH3.
DR InterPro; IPR047026; DOCK1_C2.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 9..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 446..630
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1228..1638
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1636..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1772..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1810..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 185..212
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1654..1683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1736
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1871
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1883 AA; 217413 MW; 311BEC91BAD931DF CRC64;
MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT LRKKSKKGIF
PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS TIWRQLYVQD NREMFRSVRH
MIYDLIEWRS QILSGTLPQD ELKELKKKVT AKIDYGNRIL DLDLVVRDED GNILDPELTS
TISLFRAHEI ASKQVEERLQ EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA
EVLMSLYDPV ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ
IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP FQPLALDDAV
RHKPLNMSSR FSPRVAGEND FLQTVINKVI AAKEVNHKGQ GLWVTLKLLP GDIHQIRKEF
PHLVDRTTAV ARKTGFPEII MPGDVRNDIY VTLVQGDFDK GSKTTAKNVE VTVSVYDEDG
KRLEHVIFPG AGDEAISEYK SVIYYQVKQP RWFETVKVAI PIEDVNRSHL RFTFRHRSSQ
DSKDKSEKIF ALAFVKLMRY DGTTLRDGEH DLIVYKAEVK KLEDAGTYLS LPSTKAELEE
KGHSATGKGM QSLGSCTISK DSFQISTLVC STKLTQNVDL LGLLKWRSNT NLLQQNLRQL
MKVDGGEVVK FLQDTLDALF NIMMENSESE TFDTLVFDAL VFIIGLIADR KFQHFNPVLE
TYIKKHFSAT LAYTKLTKVL RNYVDNAEKP GINDQLYKAM KALEYIFKFI VRSRILFNQL
YENKGEADFV DSLLQLFRSI NDMMSSLSDQ TVRVKGAALK YLPTIVNDVK LVFDPKELSK
MFTDFILNVP VGLLTIQKLY CLIEIVHSDL FTQHDCREIL LPMMTDQLKY HLERQEDLEA
CCQLLSNVLE VLYRKDVGPT QRHVQIIMEK LLRTVNRTVI SMGRDSELIG NFVACMTAIL
RQMEDYHYAH LIKTFGKMRT DVVDFLMETF IMFKNLIGKN VYPFDWVIMN MMQNKVFLRA
INQYADMLNK KFLDQANFEL QLWNNYFHLA VAFLTQESLQ LENFSSAKRA KILNKYGDMR
RQIGFEIRDM WYNLGQHKIK FIPEMVGPIL EMTLIPETEL RKATIPIFFD MMQCEFHSTR
SFQMFENEII TKLDHEVEGG RGDEQYKVLF DKILLEHCRK HKYLAKTGET FVKLVVRLME
RLLDYRTIMH DENKENRMSC TVNVLNFYKE IEREEMYIRY LYKLCDLHKE CDNYTEAAYT
LLLHAKLLKW SEDVCAAHLT QRDGYQATTQ GQLKEQLYQE IIHYFDKGKM WEEAIALGKE
LAEQYENEMF DYEQLSELLK KQAQFYENIV KVVRPKPDYF AVGYYGQGLP TFLRGKVFIY
RGKEYERRED FEARLLTQFP NAEKMKTTSP PGDDIKNSPG QHIQCFTVKP KLDLPPKFHR
PVSEQIVSFY RVNEVQRFEY SRPIRKGEKN PDNEFANMWI ERTVYTTAYK LPGILRWFEV
KSVFMVEISP LENAIETMQL TNDKIDSMVQ QHLDDPSLPV NPLSMLLNGI VDPAVMGGFA
NYEKAFFTDR YLQEHPEAHE KIEKLKDLIA WQIPFLAEGI RIHGEKVTEA LRPFHERMEA
CFKQLKEKVE KQYGIRTVPS SLDDRRGSRP RSMVRSFTMP SSSRPLSVAS VSSLSSDSTP
SRPGSDGFAL EPLLPKKMHS RSQDKLDKDD LDKEKKDKKK EKRNSKHQEI FDKEFKPTDI
SLQQSEAVIL SETISPLRPQ RPKSQVINVI GSERRFSVSP SSQQTPPPVT PRAKLNFSLQ
SSLELNGMTG VDVADVPPPL PLKGSTADYG NLMENQDLMG SSTPPPPPPH QKHLPPPLPS
KTPPPPPPKT TRKQTSVDSG IVQ
//
