ID   A0A2K6G2W3_PROCO        Unreviewed;       696 AA.
AC   A0A2K6G2W3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Dystrobrevin {ECO:0000256|PIRNR:PIRNR038204};
GN   Name=DTNA {ECO:0000313|Ensembl:ENSPCOP00000020568.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000020568.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000020568.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|PIRNR:PIRNR038204}.
CC   -!- SIMILARITY: Belongs to the dystrophin family. Dystrobrevin subfamily.
CC       {ECO:0000256|ARBA:ARBA00009563, ECO:0000256|PIRNR:PIRNR038204}.
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DR   AlphaFoldDB; A0A2K6G2W3; -.
DR   Ensembl; ENSPCOT00000031224.1; ENSPCOP00000020568.1; ENSPCOG00000022211.1.
DR   GeneTree; ENSGT00940000153897; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd16249; EFh_DTNA; 1.
DR   CDD; cd02334; ZZ_dystrophin; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR017432; Distrobrevin.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015153; EF-hand_dom_typ1.
DR   InterPro; IPR015154; EF-hand_dom_typ2.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   PANTHER; PTHR12268:SF19; DYSTROBREVIN ALPHA; 1.
DR   PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR   Pfam; PF09068; EF-hand_2; 1.
DR   Pfam; PF09069; EF-hand_3; 1.
DR   Pfam; PF00569; ZZ; 1.
DR   PIRSF; PIRSF038204; Distrobrevin; 2.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR038204};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00228}.
FT   TRANSMEM        672..693
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          238..294
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   REGION          468..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          381..457
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        469..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  79259 MW;  1D30B426FEB2B4B3 CRC64;
     MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE
     ALRENALNNL DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD
     PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA
     VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP
     VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT
     NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVMLESSN RLDEEHRLIA RYAARLAAES
     SSSQPTQQRS APDISFTIDA NKQQRQLIAE LENKNREILQ EIQRLRLEHE QASQPTPEKA
     QQNPTLLAEL RLLRQRKDEL EQRMSALQES RRELMVQLEG LMKLLKTQGA GSPRSSPSHT
     ISRPIPMPIR SASTCSTPMH MPQDSLTGVG GDVQEAFAQS SRRNLRNDLL VAADSITNTM
     SSLVKELNSE GGSETESNVD SEFARTQFED LVPSPTSEKA FLAQIHARKP GYIHSGATTS
     TLSSDMVTED GDPYVQPEDE NYENDSVRQL ENELKMEEYL KQKLQDEAYQ LHVSTETRLK
     HPCPVTETKW RVLFWVFVFF GGFLSLALQI YFWGLF
//