ID   A0A2K6G349_PROCO        Unreviewed;       732 AA.
AC   A0A2K6G349;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Transcription factor E2F7 {ECO:0000256|ARBA:ARBA00039675};
GN   Name=E2F7 {ECO:0000313|Ensembl:ENSPCOP00000020651.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000020651.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000020651.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC   -!- SIMILARITY: Belongs to the E2F/DP family.
CC       {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR   AlphaFoldDB; A0A2K6G349; -.
DR   Ensembl; ENSPCOT00000031308.1; ENSPCOP00000020651.1; ENSPCOG00000022301.1.
DR   GeneTree; ENSGT00940000157713; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR015633; E2F.
DR   InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR   PANTHER; PTHR12081:SF25; TRANSCRIPTION FACTOR E2F7; 1.
DR   Pfam; PF02319; E2F_TDP; 2.
DR   SMART; SM01372; E2F_TDP; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW   Nucleus {ECO:0000256|RuleBase:RU003796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU003796};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU003796}.
FT   DOMAIN          142..211
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   DOMAIN          282..367
FT                   /note="E2F/DP family winged-helix DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01372"
FT   REGION          257..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          713..732
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..625
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..647
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   732 AA;  81475 MW;  54628C2A54557D28 CRC64;
     MEVNCLTLKD LINPRQSRLD FAIEDGENAQ KENIFVDRSR MAPKTPIKNE PIDLSKQKIF
     TPERNPITPV KLVDRQQAEP WTPTANLKML ISAASPDIRD REKKKELFRP IENKDNAFTN
     SIQLVVVGNS AVDEFEKQRP SRKQKSLGLL CQKFLARYPS YPLSTEKTTI SLDEVAISLG
     VERRRIYDIV NVLESLHLVS RVAKNQYGWH GRHSLPKTLR NLQRLGEEQK YEEQMAYLQQ
     KELDLMDYKF GERKKDGYPE SQDPQLLDFS EPDYPSSSAN SRKDKSLRIM SQKFVMLFLV
     SKTKIVTLDV AAKILIEESQ DTPDHSKFKT KVRRLYDIAN VLTSLALIKK VHVTEERGRK
     PAFKWIGPVD FGSSDEELVD VSASVLPELK RETYGKIQVC AKQKLTRHCS FNTIQASERI
     QRRVNSEPSS PYREEQGSGG YSLEIGSLAA IYRQKIEDNS QGKALASKRV GPSSSSLDPA
     VPFPVLSVDS EYCVNPGLAH PVLPVTQTDL QAFSGQNGLN GQVNVSLASV ASAVESLKPA
     LLAGQPLVYI PSPSLFMLYG NLQEGPSPGS GSWSEKDGRS SEAPAAAELS SAPLAQKRLC
     EERKPEEEGE PAMKRQRREY EDSPLSLVMP KKPSDSTDFS SPKTLGGRAS TPLEDAHGNS
     QLPAAKEASG KAAANCFASS EWENPSGNID VEKPSKENES TKESSLLQYL YVQSPAVTSS
     SDPQEHPMHT VR
//