ID A0A2K6G370_PROCO Unreviewed; 359 AA.
AC A0A2K6G370;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Transcription elongation factor, mitochondrial {ECO:0000256|ARBA:ARBA00017000};
GN Name=TEFM {ECO:0000313|Ensembl:ENSPCOP00000020684.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000020684.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000020684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Transcription elongation factor which increases mitochondrial
CC RNA polymerase processivity. Regulates transcription of the
CC mitochondrial genome, including genes important for the oxidative
CC phosphorylation machinery. {ECO:0000256|ARBA:ARBA00025262}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000256|ARBA:ARBA00004436}.
CC -!- SIMILARITY: Belongs to the TEFM family.
CC {ECO:0000256|ARBA:ARBA00009086}.
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DR RefSeq; XP_012503727.1; XM_012648273.1.
DR AlphaFoldDB; A0A2K6G370; -.
DR STRING; 379532.ENSPCOP00000020684; -.
DR Ensembl; ENSPCOT00000031341.1; ENSPCOP00000020684.1; ENSPCOG00000022322.1.
DR GeneID; 105813533; -.
DR KEGG; pcoq:105813533; -.
DR CTD; 79736; -.
DR GeneTree; ENSGT00390000010581; -.
DR OMA; ESPQMAQ; -.
DR OrthoDB; 5398001at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0030337; F:DNA polymerase processivity factor activity; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:Ensembl.
DR GO; GO:0006392; P:transcription elongation by mitochondrial RNA polymerase; IEA:InterPro.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR039150; TEFM.
DR PANTHER; PTHR21053:SF2; TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL; 1.
DR PANTHER; PTHR21053; UNCHARACTERIZED; 1.
DR Pfam; PF12836; HHH_3; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
SQ SEQUENCE 359 AA; 40786 MW; 2EAEF32FD5587462 CRC64;
MSVPGLLMAA GRWRCFPIPL GSFPFQALRS SCCRKKSTAP KNIIPNVAFC DENAKESQNA
LDKLFSSEQQ ASILHVLNTA SNKELEAFKL LRGRRSTNIV EHREKFGPFQ NLESLMNVPL
FQYKTTVQVC NSILCPETGG KKKLQENRHL GKLIKPDIGR ERLKAVNSIV SIVFGTRRIA
WAHLDRKLAV LDWQQSPCWR LLDRTYSSSV YLEEISSIIS KLPKADFYVL EKTGLPIQNS
SLFPILLHFH IVEAMLYALL NETFAQDGQH QVLSMNRNAV GKHFELMIGD SRTSGKELVK
RFLSESVLKA DPRVVFPADK VVHYRQMFSS TEPQRIEELY DSLLQAIAFY ELAVFDAKP
//
