ID   A0A2K6G4C3_PROCO        Unreviewed;       882 AA.
AC   A0A2K6G4C3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=SID1 transmembrane family member 2 {ECO:0000313|Ensembl:ENSPCOP00000021068.1};
GN   Name=SIDT2 {ECO:0000313|Ensembl:ENSPCOP00000021068.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000021068.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000021068.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SID1 family.
CC       {ECO:0000256|ARBA:ARBA00006618}.
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DR   AlphaFoldDB; A0A2K6G4C3; -.
DR   STRING; 379532.ENSPCOP00000021068; -.
DR   Ensembl; ENSPCOT00000031727.1; ENSPCOP00000021068.1; ENSPCOG00000022492.1.
DR   GeneTree; ENSGT00390000010091; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0035650; F:AP-1 adaptor complex binding; IEA:Ensembl.
DR   GO; GO:0035612; F:AP-2 adaptor complex binding; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR   GO; GO:0051032; F:nucleic acid transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR   GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:Ensembl.
DR   GO; GO:0050658; P:RNA transport; IEA:Ensembl.
DR   GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
DR   GO; GO:0044342; P:type B pancreatic cell proliferation; IEA:Ensembl.
DR   InterPro; IPR025958; SID1_TM_fam.
DR   PANTHER; PTHR12185:SF16; SID1 TRANSMEMBRANE FAMILY MEMBER 2; 1.
DR   PANTHER; PTHR12185; SID1 TRANSMEMBRANE FAMILY MEMEBER; 1.
DR   Pfam; PF13965; SID-1_RNA_chan; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..882
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014353998"
FT   TRANSMEM        292..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        524..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        628..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        653..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        710..729
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        735..756
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        768..788
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   882 AA;  99921 MW;  8F3060E748E9A37E CRC64;
     MFALGLPFSV LLVALVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI YTFNHTVTRN
     RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR GLFQRKYLYQ KVERTLCQPP
     TKNESEVQFF YVDVSTLSPV NTTYQLRVSR MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE
     GVDSVIVKVT SKKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS
     NSFYVVVVVK TEDQACGGSL PFYPFVEDEP VDQGHRQKTL SVLVSQAVTS EAYVGGMLFC
     LGIFLSFYLL TVLLACWENW RQKKKTLLAA MDRACPESGH PRVLADPFPG SSPYEGYNYG
     SFENGSGSTD GLVDSEGTGD LSYSYQGHDQ FKRRLPSGQM RQLCIAMGRS FDPVGTRPRL
     DSMSSVEEDD YDTLTDIDSD KNVIRTKQYL CVADLARKDK RVLRKKYQIY FWNIATIAVF
     YALPVVQLVI TYQTVVNVTG NQDICYYNFL CAHPLGNLSA FNNILSNLGY ILLGLLFLLI
     ILQREINHNR ALLRNDLHAL ECGIPKHFGL FYAMGTALMM EGLLSACYHV CPNYTNFQFD
     TSFMYMIAGL CMLKLYQKRH PDINASAYSA YACLAIVIFF SVLGVVFGKG NTVFWIIFSI
     IHIIATLLLS TQLYYMGRWK LDSGIFRRIL HVLYTDCIRQ CSGPLYVDRM VLLVMGNIIN
     WSLAAYGLIM RPNDFASYLL AIGICNLLLY FAFYIIMKLR SGERIKLIPL LCIVCTSVVW
     GFALFFFFQG LSTWQKTPAE SREHNRDCIL LDFFDDHDIW HFLSSIAMFG SFLVGGTRPN
     WAGQVEAEVA SFSVSDLASL PQVLLTLDDD LDTVQRDKIY VF
//