ID A0A2K6G7B7_PROCO Unreviewed; 2119 AA.
AC A0A2K6G7B7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Dysferlin {ECO:0000313|Ensembl:ENSPCOP00000022121.1};
GN Name=DYSF {ECO:0000313|Ensembl:ENSPCOP00000022121.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000022121.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000022121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_012501929.1; XM_012646475.1.
DR Ensembl; ENSPCOT00000032792.1; ENSPCOP00000022121.1; ENSPCOG00000023137.1.
DR GeneID; 105812102; -.
DR CTD; 8291; -.
DR GeneTree; ENSGT00940000156187; -.
DR OMA; DAYCSVT; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546:SF44; DYSFERLIN; 1.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2085..2106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 236..354
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 393..529
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1155..1281
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1329..1457
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1600..1718
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1834..1982
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 132..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2034..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2119 AA; 240998 MW; DB3250B68BC736D9 CRC64;
MLRVFILYAE NVRTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGVPLD
QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKQ QPTGASLVLQ
VSYTPLPGAV PLFPPSTPLE PSPTLPDVDM VAGGGQSRAE TWSLLSDSTV DTRYSGKKWL
APTDTGGEED TEDQGLTGDE AEPFLDQSGA PGPGAPTTPR KPPSHPPPYH PGSKRKRSAP
TSRKLLSDKP QDFQIRVQVI EGRQLPGVNI KPVVKVTAAG HTKRTRIQKG NNPLFNETLF
FNLFDSPAEL FDEPIFITVV DSRSLRTDAL LGEFRMDVGT IYREPRHAYL RKWLLLSDPD
DFSAGARGYL KASLCVLGPG DEAPLERKDP SEDKEDIEGN LLRPTGVALR GAHFCLKVFR
AEDLPQMDDA VMDNVKQIFG FDSNKKNLVD PFVEVSFAGK MLCSKILEKT ANPQWNQNVT
LPAMFPSMCE KMRIRVIDWD RLTHNDIVAT TYLSMSKISA PGGEIEVDDH LGFLPTFGPC
YVNLYGSPRE FTGFPDPYAE LNTGKGEGVA YRGRLLLSLE TKLVEHTEQK VEDLPADDIL
RVEKFLRRRK YSLFAAFYSA SMLQDVDDAI QFEVSIGNYG NKFDTTCLPL ASTTQYSRAV
FDGCHYYYLP WGNVKPVVVL SSYWEDISHR IETQNQLLRI ADQLEAGLEQ VHLALKAQCP
TEDVDSLVAQ LMDELIADCS QPLGDVHEIP SATHLDQYLY RLRTRHLSQI TEAALALKLG
RSELPAALEQ AEDWLLRLRS LAEEPQNSLP DIIIWMLQGD KRVAYQRVPA HEVLFSRRGA
NYCGKNCGKL QTIFLKYPME KVPGSRMPVQ IRVKLWFGLS VDEKEFNQFA EGKLSVFAET
YENQTKLALV GNWGTTGLTY PKFSDVTGKI KLPKDSFRPS TGWTWAGDWF VCPEKTLLHD
TDAGHLSFVE EVFENQTRLP GGQWIYMSDN YTDVNGEKVL PKDDIECPLG WKWEDEEWST
DLNRAVDEQG WEYSITIPPD RKPRHWVPAE KMYYTHRRRR WVRLRRRDLS QMEALKRHRQ
AEAEGEGWEY ASLFGWKFHL EYRKTDAFRR RRWRRRMEPL EKTGPAAVFA LEGALGGVVD
DRSEDSMSVS TLSFGVNRPT ISCIFDYGNR YHLRCYMYQA RDLPAMDKDS FSDPYAIVSF
LHQSQKTVVA KNTLNPTWDQ TLIFYEIEIF GEPATVAEQP PSIVVEVYDH DTYGADEFIG
RCICQPSLER MPRLAWFPLM RGSQASGELL ASFELIQREK PAIYHIPGFE VQDTSRILDE
SEDTDLPYPP PQREANVYMV PQNIKPALQR TAIEILAWGL RNMKSYQLAS VSSPSLVVEC
GGQTVQSCVI RNLRKNPNFD ICTLFMEVML PREDLYCPPI TVKVIDNRQF GRRPVVGQCT
IRSLESFLCD PYSVESPSPQ GGPDDVSLLS PGEDVLIDID DKEPLIPVQL ADGLSSLAPT
NMASSPSSPH EEEFIDWWSK FFASIGESEK CGSYLEKGFD TLKVYDTQLE NVEDFEGLSD
FCNTFKLYRG KTQETEDPSV IGEFKGLFKI YPLPEDPAIP APSRQFHQLA SQGPQECLVR
IYVVRAFGLQ PKDPNGKCDP YVKISIGKKS VSDQDNYIPC TLEPVFGKMF ELTCTLPLEK
DLKITVYDYD LLSKDEKIGE TVIDLENRLL SKFGARCGLP QTYCVSGPNQ WRDQLRPSQL
LHLFCQQRRV KSPVYQTDRV LFQDKEYTIE DIEAGRTPNP HLGPVEERLA LHVLQQQGLV
PEHVESRPLY SPLQPDIEQG KLQMWVDLFP KTLGRPGPPF NITPRRARRF FLRCIIWNTR
DVILDDLSIT GEKMSDIYVK GWMVGFEEHK QKTDVHYRSL GGEGNFNWRF IFPFDYLPAE
QVCTIAKKDA FWRLDKTESK IPARVVFQIW DNDKFSFDDF LGSLQLDLNC MPKPAKTAEK
CSLDQLDDTF HPEWFVSLFE QKTVKGWWPC VAEEGEKKIL AGKLEMTLEI VAESEHEERP
AGQGRDEPNM NPKLEDPRRP DTSFLWFTSP YKTMKFILWR RFRCAIILFI ILFILLLFLG
IFVYAFPNYA AMKLVKPFS
//
