ID A0A2K6G7R3_PROCO Unreviewed; 454 AA.
AC A0A2K6G7R3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=G protein subunit alpha L {ECO:0000313|Ensembl:ENSPCOP00000022270.1};
GN Name=GNAL {ECO:0000313|Ensembl:ENSPCOP00000022270.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000022270.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000022270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(s) subfamily.
CC {ECO:0000256|ARBA:ARBA00007172}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6G7R3; -.
DR STRING; 379532.ENSPCOP00000022270; -.
DR Ensembl; ENSPCOT00000032942.1; ENSPCOP00000022270.1; ENSPCOG00000023216.1.
DR GeneTree; ENSGT00940000155271; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000367; Gprotein_alpha_S.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF233; GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00443; GPROTEINAS.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 14..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..43
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 51989 MW; 6123099809AA55B2 CRC64;
MGLCYSLRPL LFGGPGDAPC AASEPPEQDA PPAPAPAPAR TPLPWGGGTP ARARPGADPQ
EKRRRPEQSR AEEREAAREA RKVSRGIDRA LREQKRDLQR THRLLLLGRS GRGATHRLLL
LGAGESGKST IVKQMRILHV NGFNPEEKKQ KILDIRKNVK DAIVTIVSAM STIIPPVPLA
NPENQFRSDY IKSIAPITDF EYSQEFFDHV KKLWDDEGVK ACFERSNEYQ LIDCAQYFLE
RIDSVSLVDY TPTDQDLLRC RVLTSGIFET RFQVDKVNFH MFDVGGQRDE RRKWIQCFND
VTAIIYVAAC SSYNMVIRED NNTNRLRESL DLFESIWNNR WLRTISIILF LNKQDMLAEK
VLAGKSKIED YFPEYANYTV PEDATPDAGE DPKVTRAKFF IRDLFLRIST ATGDGKHYCY
PHFTCAVDTE NIRRVFNDCR DIIQRMHLKQ YELL
//
