ID A0A2K6G9X5_PROCO Unreviewed; 980 AA.
AC A0A2K6G9X5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=EMAP like 4 {ECO:0000313|Ensembl:ENSPCOP00000023044.1};
GN Name=EML4 {ECO:0000313|Ensembl:ENSPCOP00000023044.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000023044.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000023044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR AlphaFoldDB; A0A2K6G9X5; -.
DR Ensembl; ENSPCOT00000033719.1; ENSPCOP00000023044.1; ENSPCOG00000023644.1.
DR GeneTree; ENSGT00940000158434; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR CDD; cd21950; TD_EMAP4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF11; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 227..295
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 504..536
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 587..619
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 716..757
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 829..863
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 60..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..51
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 72..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 108932 MW; B1F5BAA7AD28F431 CRC64;
MDGFAGSLDD SISAASTSDV QDRLSALELR VQQQEDEITV LKAALADVLR RLAISEDHVA
SVKKSVPGKG QPSLREPSTS CKTSDSGTNR KPSYASSVSI ARKQTLSSAA KSGTEKKKEK
PQGQREKKEE SHPNDQSPQI RASPSPQPSS QPLQIHRQTP ESKNPTPTKS IKRSSTDEKS
HNPWENPDDS PNKLLRTPST SKLIPKVIKN ADKHKDVIIN QEGEYVKMFM RGRPITMFIP
SDVDNYDDIR TELPPEKLKL EWVYGYRGKD CRANVYLLPT GEIVYFIASV VVLFNYEERT
QRHYLGHTDC VKCLAIHPDK MRIATGQIAG VDKDGRPLQP HVRVWDSVSL STLQIIGLGT
FERGVGCLGF SKADSGVHLC VIDDSNEHML TVWDWQKKSK GAEIKTTNEV VLAVEFHPTD
ANTIITCGKS HIFFWTWSGN SLTRKQGIFG KYEKPKFVQC LAFLGNGDVL TGDSGGVMLI
WSKTTVEPPP GKGPKGVYQI SKQIKAHDGS VFTLCQMRNG MLLTGGGKDR KIILWDHDLN
PEREIEVPDQ YGTIRAVAEG KADQFLVGTS RNFILRGTFN DGFQIEVQGH TDELWGLATH
PFKDLLLTCA QDRQVCMWNS VEHRLEWTRL VDEPGHCADF HPSGTVVAIG THSGRWFVLD
AETRDLVSIH TDGNEQLSVV RYSIDGTFLA VGSHDNFIYL YVVSENGRKY SRYGKCNGHS
SYITHLDWSP DNKFIMSNSG DYEILHWDIP NGCKLIRNRS DCKDIDWTTY TCVLGFQVFG
VWPEGSDGTD INALVRSHNR KVIAVADDFC KVHLFQYPCS KAKAPSHKYS AHSSHVTNVS
FTHNDSHLIS TGGKDMSIIQ WKLVEKLPLP QNEIVADTAL TKAPISSIES IVQSNTPTPP
PSQPLNETAE EESRISSSPT LLENSLEQTM EPSEEHSEEQ SEGGSEDLGE PVYGEPSNGK
SEEQNEAALP EDQRDPSPLS
//
