ID   A0A2K6GAB9_PROCO        Unreviewed;       153 AA.
AC   A0A2K6GAB9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=NPC intracellular cholesterol transporter 2 {ECO:0000256|ARBA:ARBA00021477};
DE   AltName: Full=Epididymal secretory protein E1 {ECO:0000256|ARBA:ARBA00032516};
GN   Name=NPC2 {ECO:0000313|Ensembl:ENSPCOP00000023195.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000023195.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000023195.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the NPC2 family.
CC       {ECO:0000256|ARBA:ARBA00006370}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K6GAB9; -.
DR   Ensembl; ENSPCOT00000033873.1; ENSPCOP00000023195.1; ENSPCOG00000023731.1.
DR   GeneTree; ENSGT00390000006223; -.
DR   OMA; VDIKWEL; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IEA:InterPro.
DR   CDD; cd00916; Npc2_like; 1.
DR   Gene3D; 2.60.40.770; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033916; ML_Npc2-like.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR   PANTHER; PTHR11306:SF73; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..153
FT                   /note="NPC intracellular cholesterol transporter 2"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014409480"
FT   DOMAIN          24..145
FT                   /note="MD-2-related lipid-recognition"
FT                   /evidence="ECO:0000259|SMART:SM00737"
SQ   SEQUENCE   153 AA;  17033 MW;  727B4A03E4B29DD7 CRC64;
     MRFLDAAFLF LALSTAAQAE PVQFKDCGSV VGVIKEVNVS PCSTQPCQLS KGQSYSINVT
     FTSNTLSKSS KAFVHGIIMG VPVPFPIPEP DGCKSGISCP IQKDKTYSYL NKLPVKSEYP
     SIKLVVEWEL RDDQDQRLFC WEIPIQIEEG RRK
//