ID   A0A2K6GAW6_PROCO        Unreviewed;      1123 AA.
AC   A0A2K6GAW6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=UPF1 RNA helicase and ATPase {ECO:0000313|Ensembl:ENSPCOP00000023366.1};
GN   Name=UPF1 {ECO:0000313|Ensembl:ENSPCOP00000023366.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000023366.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000023366.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
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DR   AlphaFoldDB; A0A2K6GAW6; -.
DR   Ensembl; ENSPCOT00000034044.1; ENSPCOP00000023366.1; ENSPCOG00000023813.1.
DR   GeneTree; ENSGT00940000157413; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd21407; 1B_UPF1-like; 1.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 2.40.30.230; -; 1.
DR   Gene3D; 6.10.140.1240; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR040812; UPF1_1B_dom.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF539; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF18141; UPF1_1B_dom; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          109..266
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          39..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..149
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          131..159
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          177..207
FT                   /note="C4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          1003..1052
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1067..1090
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1031..1052
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1123 AA;  124029 MW;  A8D4CC6501141FBC CRC64;
     MSVEAYGPSS QTLTFLDTEE AELLGADTQG SEFEFTDFTL PSQTQTPPGC GGAGGPSGTG
     AGAAAGQLDA QVGPEGILQN GAVDDSVAKT SQLLAELNFE EDEEDTYYTK DLPVHACSYC
     GIHDPACVVY CNTSKKWFCN GRGNTSGSHI VNHLVRAKCK EVTLHKDGPL GETVLECYNC
     GCRNVFLLGF IPAKADSVVV LLCRQPCASQ SSLKDINWDS SQWQPLIQDR CFLSWLVKIP
     SEQEQLRARQ ITAQQINKLE ELWKENPSAT LEDLEKPGVD EEPQHVLLRY EDAYQYQNIF
     GPLVKLEADY DKKLKESQTQ DNITVRWDLG LNKKRIAYFT LPKTDSGNED LVIIWLRDMR
     LMQGDEICLR YKGDLAPLWK GIGHVIKVPD NYGDEIAIEL RSSVGAPVEV THNFQVDFVW
     KSTSFDRMQS ALKTFAVDET SVSGYIYHKL LGHEVEDVII KCQLPKRFTA QGLPDLNHSQ
     VYAVKTVLQR PLSLIQGPPG TGKTVTSATI VYHLARQGNG PVLVCAPSNI AVDQLTEKIH
     QTGLKVVRLC AKSREAIDSP VSFLALHNQI RNMDSMPELQ KLQQLKDETG ELSSADEKRY
     RALKRTAERE LLMNADVICC TCVGAGDPRL AKMQFRSILI DESTQATEPE CMVPVVLGAK
     QLILVGDHCQ LGPVVMCKKA AKAGLSQSLF ERLVVLGIRP IRLQVQYRMH PALSAFPSNI
     FYEGSLQNGV TAADRVKKGF DFQWPQPDKP MFFYVTQGQE EIASSGTSYL NRTEAANVEK
     ITTKLLKAGA KPDQIGIITP YEGQRSYLVQ YMQFSGSLHT KLYQEVEIAS VDAFQGREKD
     FIILSCVRAN EHQGIGFLND PRRLNVALTR ARYGVIIVGN PKALSKQPLW NHLLNYYKEQ
     KVLVEGPLNN LRESLMQFSK PRKLVNTINP GARFMTTAMY DAREAIIPGS VYDRSSQGRP
     SNMYFQTHDQ IGMISAGPSH VAAMNIPIPF NLVMPPMPPP GYFGQANGPA AGRGTPKGKT
     GRGGRQKNRF GLPGPSQTTL PNSQASQDVA SQPFSQGALT QGYISMSQPS QMSQPGLSQP
     ELSQDSYLGD EFKSQIDVAL SQDSTYQGER AYQHGGVTGL SQY
//