ID   A0A2K6GBG3_PROCO        Unreviewed;       259 AA.
AC   A0A2K6GBG3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Aquaporin 8 {ECO:0008006|Google:ProtNLM};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000023585.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000023585.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR   AlphaFoldDB; A0A2K6GBG3; -.
DR   STRING; 379532.ENSPCOP00000023585; -.
DR   Ensembl; ENSPCOT00000034265.1; ENSPCOP00000023585.1; ENSPCOG00000023941.1.
DR   GeneTree; ENSGT00940000159304; -.
DR   OMA; SVEVAMC; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015250; F:water channel activity; IEA:UniProt.
DR   CDD; cd00333; MIP; 1.
DR   Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR023277; Aquaporin_8.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   PANTHER; PTHR45665; AQUAPORIN-8; 1.
DR   PANTHER; PTHR45665:SF9; AQUAPORIN-8; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR02020; AQUAPORIN8.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; Aquaporin-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000477};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000477}.
FT   TRANSMEM        34..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   259 AA;  27591 MW;  56850929B75A4CED CRC64;
     MSVEVAMCDS NIGNAKAKEP STGDRWRVSW YEQLVQPCLA ELLGSALFIF IGCLSVIENG
     TDTGLLQPAL AHGLAMGTII ATLGNISGGH LNPAASLMAM LSGGLTLMML VPYWISQLLG
     GLIGAALAKV VSPEERFWNA TGGAFVTVQE QGQVVRALVA EVILTVLALV ICTGVTKERT
     TRPVAPFYIG LSVTMIVLAG GNVSGACMNP ARAFGPAVMA NHWGFHWIYW VGPFLAALLV
     GLFIRFFIYR RSHQSLNGQ
//