ID A0A2K6GC80_PROCO Unreviewed; 320 AA.
AC A0A2K6GC80;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 {ECO:0000256|ARBA:ARBA00015852};
DE AltName: Full=Multisynthase complex auxiliary component p38 {ECO:0000256|ARBA:ARBA00032155};
DE AltName: Full=Protein JTV-1 {ECO:0000256|ARBA:ARBA00031241};
GN Name=AIMP2 {ECO:0000313|Ensembl:ENSPCOP00000023829.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000023829.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000023829.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_012494484.1; XM_012639030.1.
DR AlphaFoldDB; A0A2K6GC80; -.
DR STRING; 379532.ENSPCOP00000023829; -.
DR Ensembl; ENSPCOT00000034509.1; ENSPCOP00000023829.1; ENSPCOG00000024068.1.
DR GeneID; 105806014; -.
DR KEGG; pcoq:105806014; -.
DR CTD; 7965; -.
DR GeneTree; ENSGT00390000015826; -.
DR OMA; LCQHYRV; -.
DR OrthoDB; 4146269at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl.
DR CDD; cd03200; GST_C_AIMP2; 1.
DR Gene3D; 1.20.1050.130; -; 1.
DR InterPro; IPR042360; AIMP2.
DR InterPro; IPR031889; AIMP2_LysRS-bd.
DR InterPro; IPR041503; AIMP2_thioredoxin.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR PANTHER; PTHR13438; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR13438:SF2; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2; 1.
DR Pfam; PF16780; AIMP2_LysRS_bd; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF18569; Thioredoxin_16; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..43
FT /note="AIMP2 lysyl-tRNA synthetase binding"
FT /evidence="ECO:0000259|Pfam:PF16780"
FT DOMAIN 118..208
FT /note="AIMP2 thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18569"
FT DOMAIN 245..308
FT /note="Glutathione S-transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00043"
SQ SEQUENCE 320 AA; 35308 MW; 7ACD4A1A186A4291 CRC64;
MPMYQVKPYH GGSAPLRVEL PTCMYRLPNV HGRTGCGTPD SGHVQEESDP SLQALESRQD
DILKRLYELK AAVDGLSKMI QTPDADLDVT NIIQADEPTA LTTNALDLNS VLGKDYGALK
DIVINANPAS PPLSLLVLHR LLCDHYRVLS TVHTHSSVKS VPENLLKCFG EQTKKRPRHE
YQLGFTLIWK NVPKTQMKFS VQTMCPIEGE GNIARFLFSL FGQKHNAVNA TLIDSWVDIA
IFQLKEGSSK EKAAVFRSMN SALGKSPWLA GNELTVADIV LWSVLQQTGG CSAAVPANVQ
RWMRSCENLA PFNSALKLLK
//
