ID A0A2K6GCS4_PROCO Unreviewed; 504 AA.
AC A0A2K6GCS4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit beta 4 {ECO:0000313|Ensembl:ENSPCOP00000024028.1};
GN Name=CACNB4 {ECO:0000313|Ensembl:ENSPCOP00000024028.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000024028.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000024028.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
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DR AlphaFoldDB; A0A2K6GCS4; -.
DR Ensembl; ENSPCOT00000034708.1; ENSPCOP00000024028.1; ENSPCOG00000024069.1.
DR GeneTree; ENSGT00950000182837; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12043; SH3_CACNB4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF7; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 67..136
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 141..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 56296 MW; EAF0A586BE43B134 CRC64;
LPASVSQVAG TTGTRHDTRL IFLSGSADSY TSRPSDSDVS LEEDREAIRQ EREQQAAIQL
ERAKSKPVAF AVKTNVSYCG ALDEDVPVPS TAISFDAKDF LHIKEKYNND WWIGRLVKEG
CEIGFIPSPL RLENIRIQQE QKRGRFHGGK SSGNSSSSLG EMVSGTFRAT PTSTGALGLT
LSCVSNHLFQ TEHIPPYDVV PSMRPVVLVG PSLKGYEVTD MMQKALFDFL KHRFDGRISI
TRVTADISLA KRSVLNNPSK RAIIERSNTR SSLAEVQSEI ERIFELARSL QLVVLDADTI
NHPAQLIKTS LAPIIVHVKV SSPKVLQRLI KSRGKSQSKH LNVQLVAADK LAQCPPEMFD
VILDENQLED ACEHLGEYLE AYWRATHTTS STPMTPLLGR NLGSTALSPY PTAISGLQSQ
RMRHSNHSTE NSPIERRSLM TSDENYHNER ARKSRNRLSS SSQHSRDHYP LVEEDYPDSY
QDTYKPHRNR GSPGGYSHDS RHRL
//
