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Database: UniProt
Entry: A0A2K6GD83_PROCO
LinkDB: A0A2K6GD83_PROCO
Original site: A0A2K6GD83_PROCO 
ID   A0A2K6GD83_PROCO        Unreviewed;      2299 AA.
AC   A0A2K6GD83;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Protein transport protein sec16 {ECO:0000256|RuleBase:RU364101};
GN   Name=SEC16A {ECO:0000313|Ensembl:ENSPCOP00000024191.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000024191.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000024191.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in the organization of the endoplasmic reticulum
CC       exit sites (ERES), also known as transitional endoplasmic reticulum
CC       (tER). Required for secretory cargo traffic from the endoplasmic
CC       reticulum to the Golgi apparatus. {ECO:0000256|RuleBase:RU364101}.
CC   -!- SUBUNIT: SEC16A and SEC16B are each present in multiple copies in a
CC       heteromeric complex. {ECO:0000256|RuleBase:RU364101}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004395}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the SEC16 family.
CC       {ECO:0000256|ARBA:ARBA00005927, ECO:0000256|RuleBase:RU364101}.
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DR   Ensembl; ENSPCOT00000034871.1; ENSPCOP00000024191.1; ENSPCOG00000024264.1.
DR   GeneTree; ENSGT00940000159324; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:InterPro.
DR   GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd09233; ACE1-Sec16-like; 1.
DR   Gene3D; 1.25.40.1030; -; 1.
DR   InterPro; IPR024298; ACE1_Sec16_Sec31.
DR   InterPro; IPR024880; Sec16.
DR   InterPro; IPR024340; Sec16_CCD.
DR   PANTHER; PTHR13402:SF13; PROTEIN TRANSPORT PROTEIN SEC16A; 1.
DR   PANTHER; PTHR13402; RGPR-RELATED; 1.
DR   Pfam; PF12932; Sec16; 1.
DR   Pfam; PF12931; Sec16_C; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU364101};
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU364101};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU364101};
KW   Membrane {ECO:0000256|RuleBase:RU364101};
KW   Protein transport {ECO:0000256|RuleBase:RU364101};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU364101}.
FT   DOMAIN          1435..1532
FT                   /note="Sec16 central conserved"
FT                   /evidence="ECO:0000259|Pfam:PF12932"
FT   DOMAIN          1605..1843
FT                   /note="Ancestral coatomer element 1 Sec16/Sec31"
FT                   /evidence="ECO:0000259|Pfam:PF12931"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          469..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          548..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          743..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          998..1096
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1116..1144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1204..1233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1311..1360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1888..1908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1968..2095
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2128..2156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2225..2299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..536
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..645
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        754..779
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        998..1021
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1053..1096
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1116..1132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1311..1342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1343..1360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1888..1904
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1993..2021
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2049..2063
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2074..2095
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2272..2288
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2299 AA;  247438 MW;  506295082C991C36 CRC64;
     MQPPPQAVPS GVAGPPPAGN PQSMFWANSP YRRRTNNNVP VAPITCPLQP VTDPFAFSRQ
     ALQNTPLGSL SKSSPPILQS SAPPGFPQCP GLPVPHTDAR DSSQGPCEPL PRPLSQPRAD
     ASSFSGALTP SALPRAETIR SAEVRPGSEP GVQAPPYLPH YIPGVGPDTS QGTHLHGNLP
     GPDQPLSRQN PPDGVVAPAA SPFSPQPCQQ MLGQWGPVQA SPQPSGQHYS PCPEGPVQSA
     APHATSVPHL PPSSSPHQGV GHEQQNQLVS LSAPLASDRR SEVAHPQSGS YSANNFDPEN
     TFRQNPRVGN TWASQEFRQN PGVTKEHWPA PTLVSPVTQG GHPENHVHYA PRTGASLSLP
     DTDSGALSMF FQGGETENEE NLSSEKAGSA GKSDFDGFSS SPGLGHPPPL VHMAAGGICQ
     GFLKGSNIET THDMWGDTAS AGTQGASSSQ CENIENLEFV QNQEVLPSES LNLDPSSPGD
     QFRYGVLPGP AVPRHNVVGH TGAPEAAMHP ARSDSVSSSY SSKSHRNLSS STRPQELVGT
     FIQQEVGKPE DEVSGSFFKQ IDSSPVGGET DESTVSQNYH SSVSQPSTPS PPKPTGIFQT
     SANSSFEPVK SHLVGVKPVE VDRANVVGEV RGTRARQKKR RPPDASPGNL EQPPDNMETF
     FAPQVCPLPV NTTAEAGHVL PHSGAPPLDT VYPTPDRKPS GRAQGMVKCE SPATTLWAQN
     ELPDFGGNVL LAPAAPALQV PAKPQPSAVV QPPEEVVSGQ QSQKPSSASP LQNRDGIGAS
     ENLENPPNVG EEEALQPQAS SGHADALPSP PAESLLHLPV LMAQPDQNYN LAQPVNFFVS
     LSNPNGKNQS WRDASVGDKP PVDSGVLSGD SGENIPLSGI PASSVLNLSL PSSLAHSNFP
     QDSGSSEMIS NQLANLLVQP PSHPLPKNLV LESQKNHNAE NVLPEFVNSP AGSTSVMLVP
     PADSTVVPNS TKANHSGNRE KTYGALDFTL NRTLENPVRM YSPSRSDGLA SQHTLGNHPG
     QSGPGPCNPD RFYQQVMKDA QDQPGLGGAL QELVPPQQQN SPPQVPKATS AESSNAESLP
     AQGQSQNSAQ APASLAPVDT GQQLLPQASS VSLVSIGSSQ AATQSEQQWP QPTPPHTLGP
     PPQDLASYYY YRPLYDGYQS QYPSLYPPDP GAASLYYPDV YGLYEPRYRP YDSTASAYAE
     NYRYPEPERP SSRASHCSDR PPPRQGYPDG YYNSKSGWSS QSDYYANYYS SQYDYGGMYR
     FHYSARFKDP RTCDRRYWCD VEYDPYRKEP YAYGDRPEKC DDSWRYDPRF TGSFDDNPEP
     HRDPYGEEVD RRSVHSEHSA RSLRSAHSLP SRRSSLSSHS QIYRSHNVTA GSYEAPLPPG
     SFRGDYAYGT YGSNFHGAQG FPEYGYAADS GWSTVEQVPS RPTSPEKFSV PHICARFGPG
     GQLIKVLPNL PSEGQPALVE IHSMETLLQH TSEQEEMRAF PGPLGKGDTH KVDVINFAQN
     KATKCLQDEN LIDRESASLL WNFIVLLCRQ NGTVVGTDIA ELLLRDHRTV WLPGKSPNEA
     NLIDFTNEAV EHVEEEEPGE AQLSFLTDSQ PATASTLEKE TERFRELLLY GRKKDALESA
     MKNGLWGHAL LLASKMDSRT HARVMTRFAN SLPINDPLQT VYQLMSGRMP AASMGPCCGQ
     AYEKWGDWRP HLAMVLSNLN NNVDVESRTM ATMGDTLASK GLLDAAHFCY LMAQVGFGVY
     TKKSTKLVLI GSNHSLPFSK FATNEAIQRT EAYEYARSLG AQSSPLPDFQ VFKFIYSCRL
     AEMGLATQAF HYCEVIAKSI LTRPHEYSPV LISQLIQVAS QLQLFDPQLK EKPEEESFVQ
     PTWLVHLQHV EKQIKEGIVV WSQDGAFPQQ CPSTPSSEVG QSDGPGLGQQ ADLETDNLLL
     VVPAPSTDHL SQGVRLLPSA PQTLSDGQLA SPARVPMFPV LPSPGPLEPG PGYGLPGSAP
     ALYPGPGLPP GTPSLQESRQ LQESRSTDPG TLPQEAPVGN SLSELSEEDF GGKFANLDPS
     RAARDSETPT GWDRTNLGSA QPPLSLTPAP ERKRPGQAVK KEVKEPKKSE SWFSRWLPGK
     KRTEAYLPDD KNKSIVWDEK KNQWVNLNEP EEEKKAPPPP PTAFPKAVQA APTGPAGVNV
     FSRRAAGTRA RYVDVLNPHG TQRSEPALPP ADFFAPLAPL PIPASFAPNP GRRSEILDRM
     TASCTLSFTD AEEPQLANGA GGEGQAPAGG QASPEAPGNL PSAGGTVPFY NPAQMAQASA
     TSGSSRPGRI GQRKYLALN
//
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