ID A0A2K6GE70_PROCO Unreviewed; 489 AA.
AC A0A2K6GE70;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Docking protein 3 {ECO:0000313|Ensembl:ENSPCOP00000024520.1};
GN Name=DOK3 {ECO:0000313|Ensembl:ENSPCOP00000024520.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000024520.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000024520.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOK family. Type A subfamily.
CC {ECO:0000256|ARBA:ARBA00010955}.
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DR AlphaFoldDB; A0A2K6GE70; -.
DR STRING; 379532.ENSPCOP00000024520; -.
DR Ensembl; ENSPCOT00000035203.1; ENSPCOP00000024520.1; ENSPCOG00000024459.1.
DR GeneTree; ENSGT00940000161724; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR CDD; cd01203; PTB_DOK1_DOK2_DOK3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037751; Dok1/2/3_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF42; DOCKING PROTEIN 3; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT DOMAIN 202..306
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 51945 MW; 700E3B40353689C3 CRC64;
LRSDAHTQLT RCRPGHGGSG SGQKGKCEEF PSSLSPVSSG FRSGSPVSAE APVKDGILYQ
QHVKFGKKSW RKVWALLYAG GPSGVARLES WEVRDGGLGP AGDRSTGPGR RGERRGIRLA
DCVSVLPADG ESCPRDTGAF LLTTTERSHL LAAQHRQAWM GPICQLAFPG TGESSSGSGQ
AESPKRGPVP MEENSIYSSW QEAGEFPVVV QRTEAAARCL LKGPYLLVLG QDAIQLRDPA
GPQALYSWPY RFLRKFGSDK GVFSFEAGRR CDSGEGLFAF SSSRAPDLCG AMAAAIARQR
ERLPELTGPR PCPLPRATSL PSLDPPGELR EVPLGHEPPT SRRVRLAEPG PQSLPLLLGP
APDEPAASGL YAAVCKRASG PPAAAEHLYE NLCKPEAGPS PPDAGPDPQE GPGARSPLAS
PIYHNSEDLS WPGPAQDSSL EAQYRRLLEL EPDEAGGTGR PGAQAGFKAK LVTLLSRERR
KGPAPCDRP
//
